Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.50 |
| ▸ | HTR3B | O95264 | 1/20 | 0.50 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.50 |
| ▸ | HTR3A | P46098 | 1/20 | 0.50 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.50 |
| ▸ | HTR3C | Q8WXA8 | 1/20 | 0.50 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.50 |
| ▸ | CHIA | Q9BZP6 | 1/20 | 0.43 |
| ▸ | LTA4H | P09960 | 2/20 | 0.42 |
| ▸ | DRD4 | P21917 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.41 |
| ▸ | AKR1C3 | P42330 | 3/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 3/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4069242 | 0.88 | HTR3E (0.47) | HTR3EHTR3BADRB1HTR3AHTR3D | |
| SCHEMBL4074886 | 0.86 | HTR3E (0.59) | HTR3EHTR3BADRB1HTR3AHTR3D | |
| SCHEMBL5276484 | 0.81 | SIGMAR1 (0.48) | HTR3EHTR3BADRB1HTR3AHTR3D | |
| SCHEMBL6399527 | 0.78 | MAPT (0.46) | DRD4ALDH1A1LMNAMAPTKDM4E | |
| SCHEMBL2127395 | 0.78 | MAPT (0.52) | ALDH1A1LMNAHTTSMN1; SMN2MAPT | |
| SCHEMBL4067323 | 0.78 | MAPT (0.50) | DRD4ALDH1A1AKR1C3LMNAHPGD | |
| SCHEMBL4071866 | 0.78 | ADRB1 (0.50) | ADRB1ALDH1A1AKR1C3LMNAHPGD | |
| SCHEMBL150538 | 0.77 | SIGMAR1 (0.46) | HTR3EHTR3BADRB1HTR3AHTR3D | |
| SCHEMBL11771698 | 0.77 | HTR3E (0.58) | HTR3EHTR3BADRB1HTR3AHTR3D | |
| SCHEMBL4067588 | 0.76 | HTR3E (0.56) | HTR3EHTR3BADRB1HTR3AHTR3D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-103328446-A | Novel 4-amino-n-hydroxy-benzamides for the treatment of cancer | HOFFMANN LA ROCHE | 2013-09-25 | — | — | CN | claimed |
| CN-1149191-C | Azetidine derivatives, Preparation and medicines containing them | ���ĵ�˹ҩ��ɷ�����˾ | 2004-05-12 | — | — | CN | claimed |
| CN-1473040-A | Association and medicinal composition of CB1 receptor antagonist and sibutramin for treating obesity | ���ĵ�˹ҩ��ɷ�����˾ | 2004-02-04 | — | — | CN | claimed |
| CN-1316991-A | Azetidine derivatives, preparation and medicines containing them | AVENTIS PHARMA SA (FR) | 2001-10-10 | — | — | CN | claimed |
| CN-103328446-A | Novel 4-amino-n-hydroxy-benzamides for the treatment of cancer | HOFFMANN LA ROCHE | 2013-09-25 | — | — | CN | disclosed |
| CN-103068830-A | Arginase inhibitors and therapeutic uses thereof | MARS INC | 2013-04-24 | — | — | CN | disclosed |
| EP-1415986-B1 | SPIRO ISOBENZOFURANES AS NEUROPEPTIDE Y RECEPTOR ANTAGONISTS | BANYU PHARMA CO LTD (JP) | 2009-04-08 | — | — | EP | disclosed |
| CN-100409845-C | Combination form of CB1 receptor antagonist and sibutramine, pharmaceutical composition thereof and application of pharmaceutical composition in preparation of drugs for treating obesity | AVENTIS PHARMA SA (FR) | 2008-08-13 | — | — | CN | disclosed |
| US-7205417-B2 | Spiro compounds | BANYU PHARMACEUTICAL CO., LTD. (JP) | 2007-04-17 | — | — | US | disclosed |
| CN-1538956-A | Spiro compounds | ������ҩ��ʽ���� | 2004-10-20 | — | — | CN | disclosed |
| CN-1149191-C | Azetidine derivatives, Preparation and medicines containing them | ���ĵ�˹ҩ��ɷ�����˾ | 2004-05-12 | — | — | CN | disclosed |
| CN-1473040-A | Association and medicinal composition of CB1 receptor antagonist and sibutramin for treating obesity | ���ĵ�˹ҩ��ɷ�����˾ | 2004-02-04 | — | — | CN | disclosed |
| CN-1316991-A | Azetidine derivatives, preparation and medicines containing them | AVENTIS PHARMA SA (FR) | 2001-10-10 | — | — | CN | disclosed |