Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.47 |
| ▸ | HTR3B | O95264 | 1/20 | 0.47 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.47 |
| ▸ | HTR3A | P46098 | 1/20 | 0.47 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.47 |
| ▸ | HTR3C | Q8WXA8 | 1/20 | 0.47 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | CHIA | Q9BZP6 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 3/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | LTA4H | P09960 | 2/20 | 0.40 |
| ▸ | DRD4 | P21917 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4068045 | 0.88 | HTR3E (0.50) | HTR3EHTR3BADRB1HTR3AHTR3D | |
| SCHEMBL4067417 | 0.80 | MAPT (0.49) | SMN1; SMN2ALDH1A1LMNAHPGDHTT | |
| SCHEMBL4070572 | 0.80 | ADRB1 (0.47) | ADRB1SMN1; SMN2ALDH1A1LMNAAKR1C3 | |
| SCHEMBL1870787 | 0.79 | LMNA (0.43) | HTR3EHTR3BADRB1HTR3AHTR3D | |
| SCHEMBL24103508 | 0.78 | SIGMAR1 (0.64) | HTR3EHTR3BADRB1HTR3AHTR3D | |
| SCHEMBL1822749 | 0.78 | HTR3E (0.64) | HTR3EHTR3BADRB1HTR3AHTR3D | |
| SCHEMBL4070180 | 0.78 | HTR3E (0.53) | HTR3EHTR3BADRB1HTR3AHTR3D | |
| SCHEMBL708442 | 0.76 | ALDH1A1 (0.63) | HTR3EHTR3BADRB1HTR3AHTR3D | |
| SCHEMBL708444 | 0.76 | ALDH1A1 (0.63) | HTR3EHTR3BADRB1HTR3AHTR3D | |
| SCHEMBL4066583 | 0.76 | CHKA (0.63) | ALDH1A1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1415986-B1 | SPIRO ISOBENZOFURANES AS NEUROPEPTIDE Y RECEPTOR ANTAGONISTS | BANYU PHARMA CO LTD (JP) | 2009-04-08 | — | — | EP | disclosed |
| US-7205417-B2 | Spiro compounds | BANYU PHARMACEUTICAL CO., LTD. (JP) | 2007-04-17 | — | — | US | disclosed |
| CN-1538956-A | Spiro compounds | ������ҩ��ʽ���� | 2004-10-20 | — | — | CN | disclosed |