Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.41 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.41 |
| ▸ | USP2 | O75604 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | PER2 | O15055 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | DTYMK | P23919 | 1/20 | 0.37 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.37 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.37 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.37 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.37 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4206491 | 0.81 | DTYMK (0.49) | KMT2AMEN1DDB1CRBNUSP2 | |
| SCHEMBL16365258 | 0.80 | ADRA1D (0.48) | KMT2AMEN1DDB1CRBNUSP2 | |
| SCHEMBL189570 | 0.76 | FPR2 (0.51) | DDB1CRBNSMN1; SMN2MAPTHPGD | |
| SCHEMBL8892804 | 0.76 | KDM4E (0.55) | SMN1; SMN2HPGDTSHRALDH1A1GPR119 | |
| SCHEMBL6778385 | 0.75 | DTYMK (0.51) | KMT2AMEN1DDB1CRBNUSP2 | |
| SCHEMBL1780574 | 0.74 | USP2 (0.51) | KMT2AMEN1USP2SMN1; SMN2MAPT | |
| SCHEMBL1088328 | 0.74 | USP2 (0.51) | KMT2AMEN1DDB1CRBNUSP2 | |
| SCHEMBL29056036 | 0.73 | FPR2 (0.50) | MAPTHPGDGPR119NPC1RAB9A | |
| SCHEMBL26129542 | 0.73 | NR1H2 (0.44) | KMT2AMEN1DDB1CRBNMAPT | |
| SCHEMBL14585899 | 0.72 | PLA2G7 (0.46) | GPR119 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2032582-A1 | PYRIMIDINE DERIVATIVES AS PI3K INHIBITORS | F.HOFFMANN-LA ROCHE AG (CH) | 2009-03-11 | — | — | EP | disclosed |
| WO-2007122410-A1 | PYRIMIDINE DERIVATIVES AS PI3K INHIBITORS | F.HOFFMANN-LA ROCHE AG (CH) | 2007-11-01 | — | — | WO | disclosed |