Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGLN1 | Q9GZT9 | 4/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.55 |
| ▸ | CALCA | P06881 | 1/20 | 0.55 |
| ▸ | STAMBP | O95630 | 1/20 | 0.48 |
| ▸ | COPS5 | Q92905 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4066741 | 0.89 | EGLN1 (0.69) | EGLN1KMT2ACALCA | |
| SCHEMBL4068327 | 0.88 | EGLN1 (0.71) | EGLN1KMT2AKDM4E | |
| SCHEMBL5224738 | 0.88 | EGLN1 (0.57) | EGLN1CALCASTAMBPCOPS5 | |
| SCHEMBL6490436 | 0.83 | CALCA (0.62) | EGLN1KMT2ACALCAL3MBTL1RPS6KB1 | |
| SCHEMBL12697382 | 0.83 | EGLN1 (0.79) | EGLN1KMT2ARPS6KB1 | |
| SCHEMBL14129717 | 0.83 | EGLN1 (0.55) | EGLN1KMT2A | |
| SCHEMBL13313527 | 0.82 | ADORA2A (0.47) | EGLN1CALCAL3MBTL1 | |
| SCHEMBL4060463 | 0.82 | EGLN1 (0.57) | EGLN1CALCA | |
| SCHEMBL4060740 | 0.82 | CALCA (0.61) | EGLN1KMT2ACALCAL3MBTL1RPS6KB1 | |
| SCHEMBL7101920 | 0.81 | CALCA (0.60) | EGLN1KMT2ACALCAL3MBTL1RPS6KB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1326865-B1 | AZA- AND POLYAZA-NAPHTHALENYL CARBOXAMIDES USEFUL AS HIV INTEGRASE INHIBITORS | MERCK & CO INC (US) | 2009-05-06 | — | — | EP | disclosed |
| US-20050176718-A1 | Aza- and polyaza-naphthalenyl carboxamides useful as HIV integrase inhibitors | ANTHONY NEVILLE J (US) | 2005-08-11 | — | — | US | disclosed |
| US-6921759-B2 | Aza- and polyaza-naphthalenyl carboxamides useful as HIV integrase inhibitors | MERCK & CO., INC. (US) | 2005-07-26 | — | — | US | disclosed |
| US-20050014780-A1 | Process for preparing 5-sulfonamido-8-hydroxy-1,6-naphthyridine-7-carboxamides | MALIGRES PETER E (US) | 2005-01-20 | — | — | US | disclosed |
| EP-1427726-A1 | PROCESS FOR PREPARING 5-SULFONAMIDO-8-HYDROXY-1, 6-NAPHTHYRIDINE-7-CARBOXAMIDES | Merck & Co., Inc. (US) | 2004-06-16 | — | — | EP | disclosed |
| EP-1326865-A2 | AZA- AND POLYAZA-NAPHTHALENYL CARBOXAMIDES USEFUL AS HIV INTEGRASE INHIBITORS | Merck & Co., Inc. (US) | 2003-07-16 | — | — | EP | disclosed |
| US-20030055071-A1 | Aza- and polyaza-naphthalenyl carboxamides useful as HIV integrase inhibitors | MERCK SHARP & DOHME CORP. | 2003-03-20 | — | — | US | disclosed |
| WO-2003016309-A1 | PROCESS FOR PREPARING 5-SULFONAMIDO-8-HYDROXY-1, 6-NAPHTHYRIDINE-7-CARBOXAMIDES | MERCK & CO., INC. (US) | 2003-02-27 | — | — | WO | disclosed |
| WO-2002030930-A2 | AZA- AND POLYAZA-NAPHTHALENYL CARBOXAMIDES USEFUL AS HIV INTEGRASE INHIBITORS | MERCK & CO., INC. (US) | 2002-04-18 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030055071-A1 | Aza- and polyaza-naphthalenyl carboxamides useful as HIV integrase inhibitors | POLI, DUT, NAAA | EGLN1 2027/4885KMT2A 61/4885CALCA 3366/4885 |
| US-20050176718-A1 | Aza- and polyaza-naphthalenyl carboxamides useful as HIV integrase inhibitors | POLI, DUT, NAAA | EGLN1 2027/4885KMT2A 61/4885CALCA 3366/4885 |
| US-20050014780-A1 | Process for preparing 5-sulfonamido-8-hydroxy-1,6-naphthyridine-7-carboxamides | HNMT, HDHD5, HCLS1 | EGLN1 1240/4885KMT2A 396/4885CALCA 1749/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.