Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.56 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.56 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.52 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.50 |
| ▸ | PAOX | Q6QHF9 | 3/20 | 0.47 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.44 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.44 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.37 |
| ▸ | MTNR1A | P48039 | 3/20 | 0.36 |
| ▸ | MTNR1B | P49286 | 3/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16303450 | 0.94 | KDM4E (0.60) | KDM4EMAPK1HIF1AALDH1A1ADRA1A | |
| SCHEMBL9787817 | 0.92 | KDM4E (0.64) | KDM4EMAPK1HIF1AALDH1A1ADRA1A | |
| SCHEMBL12662715 | 0.86 | KDM4E (0.48) | KDM4EMAPK1HIF1AALDH1A1ADRA1A | |
| SCHEMBL3293381 | 0.83 | ALDH1A1 (0.52) | KDM4EMAPK1HIF1AALDH1A1ADRA1A | |
| SCHEMBL14365830 | 0.79 | ALDH1A1 (0.48) | ALDH1A1CHRNB2CHRNB4CHRNA4HTT | |
| SCHEMBL408247 | 0.77 | ALDH1A1 (0.56) | ALDH1A1CHRNB2CHRNB4CHRNA4HTT | |
| SCHEMBL3292427 | 0.77 | ALDH1A1 (0.50) | KDM4EMAPK1HIF1AALDH1A1ADRA1A | |
| SCHEMBL1687734 | 0.77 | KDM4E (0.67) | KDM4EMAPK1HIF1AALDH1A1ADRA1A | |
| SCHEMBL27941457 | 0.77 | KDM4E (0.67) | KDM4EMAPK1HIF1AALDH1A1ADRA1A | |
| SCHEMBL23901259 | 0.76 | ADRA1A (0.58) | KDM4EMAPK1HIF1AADRA1APAOX |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120065196-A1 | AMIDE COMPOUNDS | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2012-03-15 | — | — | US | disclosed |
| US-20120046292-A1 | DIACYLETHYLENEDIAMINE COMPOUND | ASTELLAS PHARMA INC. (JP) | 2012-02-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120046292-A1 | DIACYLETHYLENEDIAMINE COMPOUND | DGAT1, DGAT2, DIMT1 | KDM4E 3060/4885MAPK1 2553/4885HIF1A 3495/4885 |
| US-20120065196-A1 | AMIDE COMPOUNDS | DGAT2, DGAT1, DLAT | KDM4E 2452/4885MAPK1 2805/4885HIF1A 2417/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.