Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM2 | P08172 | 1/20 | 0.48 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.48 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.48 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.48 |
| ▸ | HTT | P42858 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.41 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.38 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 3/20 | 0.37 |
| ▸ | TP53 | P04637 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | AADAT | Q8N5Z0 | 2/20 | 0.37 |
| ▸ | GOT1 | P17174 | 1/20 | 0.37 |
| ▸ | KYAT1 | Q16773 | 1/20 | 0.37 |
| ▸ | KYAT3 | Q6YP21 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4069565 | 0.90 | CHRM2 (0.52) | CHRM2CHRM4CHRM1CHRM3HTT | |
| SCHEMBL4068085 | 0.76 | POLB (0.42) | HTTALDH1A1KDM4ELMNASMN1; SMN2 | |
| SCHEMBL4067884 | 0.76 | PYGL (0.50) | ALDH1A1KDM4ESMN1; SMN2PYGL | |
| SCHEMBL4073186 | 0.74 | KDM4E (0.60) | ALDH1A1KDM4ESMN1; SMN2KMT2ATHRB | |
| SCHEMBL4066125 | 0.74 | LMNA (0.42) | ALDH1A1KDM4ELMNASMN1; SMN2TP53 | |
| SCHEMBL4064789 | 0.74 | POLB (0.47) | ALDH1A1AADATGOT1KYAT1KYAT3 | |
| SCHEMBL4065818 | 0.73 | KDM4E (0.53) | ALDH1A1KDM4ESMN1; SMN2MEN1KMT2A | |
| SCHEMBL4064970 | 0.73 | PYGL (0.44) | ALDH1A1KDM4ELMNAMEN1KMT2A | |
| SCHEMBL5642069 | 0.73 | PYGL (0.72) | PYGL | |
| SCHEMBL4068434 | 0.72 | TSHR (0.44) | ALDH1A1LMNASMN1; SMN2MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1819332-B1 | PYRROLOPYRIDINE-2-CARBOXYLIC ACID AMIDES | PROSIDION LTD (GB) | 2009-03-11 | — | — | EP | disclosed |