Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIN1 | Q13526 | 1/20 | 0.63 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.54 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.54 |
| ▸ | PTGDR2 | Q9Y5Y4 | 4/20 | 0.49 |
| ▸ | PKN1 | Q16512 | 1/20 | 0.48 |
| ▸ | PKN2 | Q16513 | 1/20 | 0.48 |
| ▸ | APEX1 | P27695 | 1/20 | 0.47 |
| ▸ | GSK3B | P49841 | 4/20 | 0.46 |
| ▸ | CSNK1A1 | P48729 | 4/20 | 0.46 |
| ▸ | CSNK1D | P48730 | 4/20 | 0.46 |
| ▸ | CSNK1G2 | P78368 | 3/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | THRB | P10828 | 1/20 | 0.46 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.45 |
| ▸ | MLLT1 | Q03111 | 1/20 | 0.45 |
| ▸ | METAP2 | P50579 | 1/20 | 0.45 |
| ▸ | METAP1 | P53582 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4069583 | 0.89 | PIN1 (0.49) | PIN1GRIN1GRIN2BPTGDR2MLLT1 | |
| SCHEMBL7653726 | 0.82 | TDP1 (0.59) | PIN1GRIN1GRIN2BPKN1PKN2 | |
| SCHEMBL3378278 | 0.82 | HSD17B10 (0.63) | PIN1GRIN1GRIN2BPTGDR2PKN1 | |
| SCHEMBL7366450 | 0.81 | RAB9A (0.64) | PIN1GRIN1GRIN2BPKN1PKN2 | |
| SCHEMBL7381841 | 0.79 | GRIN1 (0.55) | PIN1GRIN1GRIN2BPKN1PKN2 | |
| SCHEMBL3391734 | 0.79 | GRIN1 (0.55) | PIN1GRIN1GRIN2BPKN1PKN2 | |
| SCHEMBL38661086 | 0.78 | IDO1 (0.59) | PIN1PTGDR2APEX1NPSR1ALDH1A1 | |
| SCHEMBL3214301 | 0.78 | TDP1 (0.67) | PIN1APEX1ALDH1A1 | |
| SCHEMBL7348242 | 0.78 | MAPT (0.68) | GRIN1GRIN2BAPEX1NPSR1THRB | |
| SCHEMBL20305429 | 0.78 | PIN1 (1.00) | PIN1GRIN1GRIN2BPKN1PKN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1539754-A4 | BENZIMIDAZOLE QUINOLINONES AND USES THEREOF | NOVARTIS VACCINES & DIAGNOSTIC (US) | 2009-02-25 | — | — | EP | disclosed |
| EP-1539754-A2 | BENZIMIDAZOLE QUINOLINONES AND USES THEREOF | Chiron Corporation (US) | 2005-06-15 | — | — | EP | disclosed |
| WO-2004018419-A2 | BENZIMIDAZOLE QUINOLINONES AND USES THEREOF | CHIRON CORPORATION (US) | 2004-03-04 | — | — | WO | disclosed |