SCHEMBL7366450

SCHEMBL7366450

N#Cc1ccc2nc(CC(=O)c3ccc(Br)cc3)[nH]c2c1

nearest known ligand 0.64

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
RAB9A P51151 4/20 0.64
ALDH1A1 P00352 3/20 0.64
MAPT P10636 3/20 0.64
SMN1; SMN2 Q16637 1/20 0.64
NPC1 O15118 3/20 0.51
PIN1 Q13526 1/20 0.51
GRIN1 Q05586 1/20 0.45
GRIN2B Q13224 1/20 0.45
KDM4E B2RXH2 1/20 0.45
TDP1 Q9NUW8 1/20 0.45
MLLT1 Q03111 1/20 0.45
NPSR1 Q6W5P4 1/20 0.42
HDAC6 Q9UBN7 2/20 0.42
HDAC3 O15379 1/20 0.42
HDAC4 P56524 1/20 0.42
HDAC1 Q13547 1/20 0.42
HDAC7 Q8WUI4 1/20 0.42
HDAC2 Q92769 1/20 0.42
HDAC10 Q969S8 1/20 0.42
HDAC11 Q96DB2 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7368698 0.91 RAB9A (0.64) RAB9AALDH1A1MAPTSMN1; SMN2NPC1
SCHEMBL4069591 0.81 PIN1 (0.63) ALDH1A1MAPTPIN1GRIN1GRIN2B
SCHEMBL7365671 0.78 TRPV1 (0.48) RAB9AALDH1A1MAPTSMN1; SMN2NPC1
SCHEMBL7653726 0.75 TDP1 (0.59) RAB9AALDH1A1MAPTSMN1; SMN2NPC1
SCHEMBL3378278 0.75 HSD17B10 (0.63) RAB9AALDH1A1MAPTSMN1; SMN2NPC1
SCHEMBL7381841 0.72 GRIN1 (0.55) RAB9AALDH1A1MAPTSMN1; SMN2NPC1
SCHEMBL3391734 0.72 GRIN1 (0.55) RAB9AALDH1A1MAPTSMN1; SMN2NPC1
SCHEMBL14816640 0.71 PKN1 (0.72) RAB9AALDH1A1MAPTSMN1; SMN2NPC1
SCHEMBL7651832 0.71 SMN1; SMN2 (0.73) RAB9AALDH1A1MAPTSMN1; SMN2NPC1
SCHEMBL4069583 0.70 PIN1 (0.49) RAB9AALDH1A1MAPTSMN1; SMN2NPC1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6043257-A ANTICOAGULANT; PYRIDINE SUBSTITUTED INDAZOLE COMPOUND E. I. DU PONT DE NEMOURS AND COMPANY (US) 2000-03-28 US disclosed
EP-0960102-A1 AMIDINOINDOLES, AMIDINOAZOLES, AND ANALOGS THEREOF AS INHIBITORS OF FACTOR Xa AND OF THROMBIN Du Pont Pharmaceuticals Company (US) 1999-12-01 EP disclosed
US-5886191-A ANTICOAGULANTS DUPONT PHARMACEUTICALS COMPANY (US) 1999-03-23 US disclosed
WO-1998001428-A1 AMIDINOINDOLES, AMIDINOAZOLES, AND ANALOGS THEREOF AS INHIBITORS OF FACTOR Xa AND OF THROMBIN DU PONT PHARMACEUTICALS COMPANY (US) 1998-01-15 WO disclosed