Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.51 |
| ▸ | PKM | P14618 | 2/20 | 0.50 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.50 |
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.50 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.48 |
| ▸ | HPGD | P15428 | 1/20 | 0.48 |
| ▸ | ERN1 | O75460 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 4/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | CRHBP | P24387 | 1/20 | 0.46 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | GRK6 | P43250 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14390762 | 0.91 | KDM4E (0.47) | KDM4EPKMALOX15TSHRHSD17B10 | |
| SCHEMBL29953284 | 0.88 | ERN1 (0.59) | KDM4EPKMALOX15TSHRHSD17B10 | |
| SCHEMBL1326587 | 0.82 | ALDH1A1 (0.53) | KDM4EHPGDSMN1; SMN2HTTKMT2A | |
| SCHEMBL6921762 | 0.82 | PTGDR2 (0.63) | PKMPTGDR2HPGDSMN1; SMN2POLB | |
| SCHEMBL1531280 | 0.82 | PTGDR2 (0.63) | PKMPTGDR2SMN1; SMN2POLBHTT | |
| SCHEMBL2059437 | 0.81 | PTGDR2 (0.47) | TSHRHSD17B10PTGDR2HPGDSMN1; SMN2 | |
| SCHEMBL7513156 | 0.80 | HTT (0.50) | PKMHPGDERN1SMN1; SMN2POLB | |
| SCHEMBL1326022 | 0.79 | TDP1 (0.49) | PKMTSHRHPGDERN1SMN1; SMN2 | |
| SCHEMBL12776981 | 0.79 | PKM (0.48) | PKMHSD17B10ERN1SMN1; SMN2HTT | |
| SCHEMBL28010866 | 0.79 | HTT (0.49) | PKMHPGDERN1SMN1; SMN2HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8211900-B2 | DHFR enzyme inhibitors | CHROMA THERAPEUTICS LTD. (GB) | 2012-07-03 | — | — | US | disclosed |
| US-8211900-B2 | DHFR enzyme inhibitors | CHROMA THERAPEUTICS LTD. (GB) | 2012-07-03 | — | — | US | disclosed |
| US-8211900-B2 | DHFR enzyme inhibitors | CHROMA THERAPEUTICS LTD. (GB) | 2012-07-03 | — | — | US | disclosed |
| US-20090118311-A1 | DHFR Enzyme Inhibitors | CHROMA THERAPEUTICS LTD. (GB) | 2009-05-07 | — | — | US | disclosed |
| US-20090118311-A1 | DHFR Enzyme Inhibitors | CHROMA THERAPEUTICS LTD. (GB) | 2009-05-07 | — | — | US | disclosed |
| US-20090118311-A1 | DHFR Enzyme Inhibitors | CHROMA THERAPEUTICS LTD. (GB) | 2009-05-07 | — | — | US | disclosed |
| EP-2013189-A1 | DHFR ENZYME INHIBITORS | Chroma Therapeutics Limited (GB) | 2009-01-14 | — | — | EP | disclosed |
| WO-2007132146-A1 | DHFR ENZYME INHIBITORS | CHROMA THERAPEUTICS LTD. (GB) | 2007-11-22 | — | — | WO | disclosed |
| WO-2007132146-A1 | DHFR ENZYME INHIBITORS | CHROMA THERAPEUTICS LTD. (GB) | 2007-11-22 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090118311-A1 | DHFR Enzyme Inhibitors | DHFR, MTHFD1, ALDH7A1 | KDM4E 1741/4885PKM 2867/4885ALOX15 1676/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.