Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.39 |
| ▸ | L3MBTL3 | Q96JM7 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | ACHE | P22303 | 2/20 | 0.33 |
| ▸ | NCF1 | P14598 | 1/20 | 0.32 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | RAD52 | P43351 | 1/20 | 0.32 |
| ▸ | RECQL | P46063 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | HTR7 | P34969 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2555402 | 0.86 | SIGMAR1 (0.36) | ALDH1A1SIGMAR1KDM4EKMT2A | |
| SCHEMBL29824951 | 0.82 | SIGMAR1 (0.45) | ALDH1A1SIGMAR1KDM4EHTR7KMT2A | |
| SCHEMBL13698377 | 0.80 | PAOX (0.38) | ALDH1A1SIGMAR1RAD52KMT2A | |
| SCHEMBL1655253 | 0.80 | PAOX (0.38) | ALDH1A1SIGMAR1RAD52KMT2A | |
| SCHEMBL18351064 | 0.80 | PAOX (0.38) | ALDH1A1SIGMAR1RAD52KMT2A | |
| SCHEMBL3930612 | 0.79 | L3MBTL3 (0.38) | L3MBTL1L3MBTL3ALDH1A1KDM4ERECQL | |
| SCHEMBL3932472 | 0.79 | L3MBTL3 (0.40) | L3MBTL1L3MBTL3ALDH1A1KDM4ERECQL | |
| SCHEMBL26042815 | 0.78 | L3MBTL1 (0.40) | L3MBTL1L3MBTL3ALDH1A1ACHENCF1 | |
| SCHEMBL4067143 | 0.78 | CACNA2D1 (0.43) | ACHENCF1SIGMAR1 | |
| SCHEMBL3939588 | 0.77 | ALDH1A1 (0.42) | L3MBTL1L3MBTL3ALDH1A1KDM4ERECQL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2066659-A1 | SUBSTITUTED SULFONAMIDE DERIVATIVES | Grünenthal GmbH (DE) | 2009-06-10 | — | — | EP | claimed |
| WO-2008040492-A1 | SUBSTITUTED SULFONAMIDE DERIVATIVES | Grünenthal GmbH (DE) | 2008-04-10 | — | — | WO | claimed |