Sugi Predict

Sugi Predict / Compounds / SCHEMBL1655253

SCHEMBL1655253

SCHEMBL1655253

CN1CCN(CC=O)CC1

nearest known ligand 0.38

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
▸ PAOX Q6QHF9 1/20 0.38
▸ MC4R P32245 1/20 0.35
▸ SIGMAR1 Q99720 3/20 0.34
▸ ALDH1A1 P00352 3/20 0.33
▸ LMNA P02545 1/20 0.33
▸ CYP1A2 P05177 1/20 0.33
▸ TDP1 Q9NUW8 1/20 0.33
▸ TSHR P16473 1/20 0.32
▸ CHKA P35790 1/20 0.31
▸ HTR1A P08908 1/20 0.31
▸ MEN1 O00255 1/20 0.31
▸ RAD52 P43351 1/20 0.31
▸ KMT2A Q03164 1/20 0.31
▸ ERN1 O75460 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL18351064 1.00 PAOX (0.38) PAOXMC4RSIGMAR1ALDH1A1LMNA
SCHEMBL13698377 1.00 PAOX (0.38) PAOXMC4RSIGMAR1ALDH1A1LMNA
SCHEMBL27020232 0.91 PAOX (0.33) PAOXMC4RSIGMAR1ALDH1A1HTR1A
Acetic Acid SCHEMBL6625112 0.89 PAOX (0.44) PAOXMC4RALDH1A1CYP1A2TDP1
SCHEMBL28374092 0.86 — —
SCHEMBL24335650 0.84 HSD17B10 (0.41) PAOXSIGMAR1ALDH1A1LMNATSHR
SCHEMBL2561626 0.80 DRD2 (0.39) SIGMAR1MEN1KMT2A
SCHEMBL4072907 0.80 L3MBTL1 (0.39) SIGMAR1ALDH1A1RAD52KMT2A
SCHEMBL4067143 0.80 CACNA2D1 (0.43) SIGMAR1
SCHEMBL29300025 0.79 SMN1; SMN2 (0.35) ALDH1A1TDP1MEN1RAD52KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 175 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20250241918-A1 NOVEL USE OF PYRAZOLOPYRIMIDINE COMPOUND Hefei Youyuan Pharmaceutical Co., Ltd. (CN) 2025-07-31 — — US claimed
EP-4509125-A1 NOVEL USE OF PYRAZOLOPYRIMIDINE COMPOUND Hefei Youyuan Pharmaceutical Co., Ltd. (CN) 2025-02-19 — — EP claimed
US-20240383889-A1 PYRAZOLOPYRIDINE COMPOUNDS AND USES THEREOF INCYTE CORPORATION 2024-11-21 — — US claimed
US-12083124-B2 Bicyclic heterocycles as FGFR inhibitors INCYTE CORPORATION (US) 2024-09-10 — — US claimed
US-20230338389-A1 BICYCLIC HETEROCYCLES AS FGFR INHIBITORS INCYTE CORPORATION 2023-10-26 — — US claimed
CN-116898854-A Novel application of pyrazolopyrimidine compound 安徽中科拓苒药物科学研究有限公司 2023-10-20 — — CN claimed
WO-2023197914-A1 NOVEL USE OF PYRAZOLOPYRIMIDINE COMPOUND 安徽中科拓苒药物科学研究有限公司 2023-10-19 — — WO claimed
CN-115835908-A Bicyclic heterocycles as FGFR inhibitors 因赛特公司 2023-03-21 — — CN claimed
US-11607416-B2 Bicyclic heterocycles as FGFR inhibitors INCYTE CORPORATION (US) 2023-03-21 — — US claimed
EP-4045151-A1 BICYCLIC HETEROCYCLES AS FGFR INHIBITORS Incyte Corporation (US) 2022-08-24 — — EP claimed
US-20060211698-A1 Bicyclic heteroaryl derivatives for treating viruses GENELABS, INC. 2006-09-21 — — US claimed
US-20060004084-A1 (3Z)-3-(2,3-dihydro-1H-inden-1-ylidene)-1,3-dihydro-2H-indol-2-ones as kinase inhibitors ALLERGAN, INC. 2006-01-05 — — US claimed
CN-1681817-A Biologically active compounds AMURA THERAPEUTICS LTD (GB) 2005-10-12 — — CN claimed
US-20050054710-A1 Indolinones substituted by heterocycles, the preparation thereof and their use as medicaments BOEHRINGER INGELHEIM PHARMA GMBH & CO. KG (DE) 2005-03-10 — — US claimed
CN-1168719-C 6-phenylpyridin-2-ylamine derivatives, pharmaceutical compositions and uses ������ҩ�����޹�˾ 2004-09-29 — — CN claimed
EP-1383748-A2 NOVEL COMPOUNDS AND COMPOSITIONS AS CATHEPSIN INHIBITORS AXYS PHARMACEUTICALS, INC. (US) 2004-01-28 — — EP claimed
US-6436919-B1 LOCAL ANESTHETICS THAT HAVE LONGER DURATION OF ACTION WHILE REDUCING UNDESIRED SIDE EFFECTS THERAVANCE INC. 2002-08-20 — — US claimed
WO-2002051983-A2 NOVEL COMPOUNDS AND COMPOSITIONS AS CATHEPSIN INHIBITORS AXYS PHARMACEUTICALS, INC. (US) 2002-07-04 — — WO claimed
EP-1216243-A1 QUINAZOLINONES AND ANALOGUES AND THEIR USE AS LOCAL ANESTHETICS Advanced Medicine, Inc. (US) 2002-06-26 — — EP claimed
WO-2001025234-A1 QUINAZOLINONES AND ANALOGUES AND THEIR USE AS LOCAL ANESTHETICS ADVANCED MEDICINE, INC. (US) 2001-04-12 — — WO claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20240383889-A1 PYRAZOLOPYRIDINE COMPOUNDS AND USES THEREOF PDXK, PCK1, PGK1 PAOX 902/4885MC4R 4356/4885SIGMAR1 3118/4885
US-12083124-B2 Bicyclic heterocycles as FGFR inhibitors FGFR1, FGFR3, FGFR2 PAOX 2374/4885MC4R 2172/4885SIGMAR1 4806/4885
US-20250241918-A1 NOVEL USE OF PYRAZOLOPYRIMIDINE COMPOUND NLRP3, NLRP1, CASP1 PAOX 980/4885MC4R 1153/4885SIGMAR1 2228/4885
US-20060004084-A1 (3Z)-3-(2,3-dihydro-1H-inden-1-ylidene)-1,3-dihydro-2H-indol-2-ones as kinase inhibitors CDK2, ERBB2, MAP3K3 PAOX 3525/4885MC4R 2913/4885SIGMAR1 2557/4885
US-11607416-B2 Bicyclic heterocycles as FGFR inhibitors FGFR1, FGFR3, FGFR2 PAOX 2374/4885MC4R 2172/4885SIGMAR1 4806/4885
US-20060211698-A1 Bicyclic heteroaryl derivatives for treating viruses HAVCR2, ZC3HAV1, SARS1 PAOX 1209/4885MC4R 4465/4885SIGMAR1 3246/4885
US-20050054710-A1 Indolinones substituted by heterocycles, the preparation thereof and their use as medicaments CDK1, CDK2, CDK3 PAOX 3998/4885MC4R 1184/4885SIGMAR1 1396/4885
US-20230338389-A1 BICYCLIC HETEROCYCLES AS FGFR INHIBITORS FGFR1, FGFR3, FGFR2 PAOX 2374/4885MC4R 2172/4885SIGMAR1 4806/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.