Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.63 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.63 |
| ▸ | TP53 | P04637 | 1/20 | 0.63 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.63 |
| ▸ | TSHR | P16473 | 1/20 | 0.63 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.63 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.63 |
| ▸ | IDO1 | P14902 | 5/20 | 0.52 |
| ▸ | CA12 | O43570 | 1/20 | 0.50 |
| ▸ | CA1 | P00915 | 1/20 | 0.50 |
| ▸ | CA2 | P00918 | 1/20 | 0.50 |
| ▸ | CA7 | P43166 | 1/20 | 0.50 |
| ▸ | CA9 | Q16790 | 1/20 | 0.50 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.50 |
| ▸ | AGXT | P21549 | 2/20 | 0.48 |
| ▸ | LTA4H | P09960 | 1/20 | 0.48 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.48 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.45 |
| ▸ | CALM1 | P0DP23 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL244069 | 0.81 | ALDH1A1 (0.68) | ALDH1A1ALOX15TP53CYP3A4TSHR | |
| SCHEMBL11437812 | 0.81 | ALDH1A1 (0.68) | ALDH1A1ALOX15TP53CYP3A4TSHR | |
| SCHEMBL10792996 | 0.81 | ALDH1A1 (0.57) | ALDH1A1ALOX15TP53CYP3A4TSHR | |
| SCHEMBL9982766 | 0.81 | SMN1; SMN2 (0.57) | ALDH1A1ALOX15TP53CYP3A4TSHR | |
| SCHEMBL3933929 | 0.79 | ALDH1A1 (0.65) | ALDH1A1ALOX15TP53CYP3A4TSHR | |
| SCHEMBL190915 | 0.79 | ALDH1A1 (0.65) | ALDH1A1ALOX15TP53CYP3A4TSHR | |
| SCHEMBL5598799 | 0.78 | ALDH1A1 (0.59) | ALDH1A1ALOX15TP53CYP3A4TSHR | |
| SCHEMBL8318176 | 0.77 | ALDH1A1 (0.63) | ALDH1A1ALOX15TP53CYP3A4TSHR | |
| SCHEMBL8474430 | 0.77 | ALDH1A1 (0.63) | ALDH1A1ALOX15TP53CYP3A4TSHR | |
| Estragole SCHEMBL57204 | 0.77 | ALDH1A1 (1.00) | ALDH1A1ALOX15TP53CYP3A4TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2010539-B1 | STEREOSELECTIVE REDUCTION OF A MORPHINONE | NEKTAR THERAPEUTICS (US) | 2017-06-14 | — | — | EP | disclosed |
| US-8563726-B2 | Stereoselective reduction of a morphinone | NEKTAR THERAPEUTICS (US) | 2013-10-22 | — | — | US | disclosed |
| US-20130018190-A1 | STEREOSELECTIVE REDUCTION OF A MORPHINONE | NEKTAR THERAPEUTICS (US) | 2013-01-17 | — | — | US | disclosed |
| US-8183376-B2 | Stereoselective reduction of a morphinone | NEKTAR THERAPEUTICS (US) | 2012-05-22 | — | — | US | disclosed |
| US-20090221766-A1 | STEREOSELECTIVE REDUCTION OF A MORPHINONE | NEKTAR THERAPEUTICS AL, CORPORATION (US) | 2009-09-03 | — | — | US | disclosed |
| EP-2010539-A2 | STEREOSELECTIVE REDUCTION OF A MORPHINONE | Nektar Therapeutics AL, Corporation (US) | 2009-01-07 | — | — | EP | disclosed |
| WO-2007124114-A2 | STEREOSELECTIVE REDUCTION OF A MORPHINONE | NEKTAR THERAPEUTICS AL, CORPORATION (US) | 2007-11-01 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130018190-A1 | STEREOSELECTIVE REDUCTION OF A MORPHINONE | SORD, ADH1C, ADH1A | ALDH1A1 57/4885ALOX15 1629/4885TP53 3307/4885 |
| US-20090221766-A1 | STEREOSELECTIVE REDUCTION OF A MORPHINONE | SORD, ADH1C, ADH1A | ALDH1A1 57/4885ALOX15 1629/4885TP53 3307/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.