Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 13/20 | 0.38 |
| ▸ | SLC6A2 | P23975 | 12/20 | 0.38 |
| ▸ | SLC6A4 | P31645 | 5/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.36 |
| ▸ | PNMT | P11086 | 1/20 | 0.36 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | GLA | P06280 | 1/20 | 0.35 |
| ▸ | SLC6A3 | Q01959 | 3/20 | 0.34 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.33 |
| ▸ | ADRA2B | P18089 | 2/20 | 0.33 |
| ▸ | ADRA2C | P18825 | 2/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.33 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4073220 | 0.81 | MET (0.32) | — | |
| SCHEMBL18489287 | 0.79 | HTR1A (0.40) | HTR1ASLC6A2SLC6A4CYP1A2CYP3A4 | |
| SCHEMBL4079480 | 0.76 | KMT2A (0.33) | — | |
| SCHEMBL1918390 | 0.73 | HTR1A (0.41) | HTR1ASLC6A2SLC6A4TAAR1ALDH1A1 | |
| SCHEMBL7913213 | 0.73 | ALDH1A1 (0.44) | HTR1ASLC6A2SLC6A4CYP1A2CYP3A4 | |
| SCHEMBL4071654 | 0.70 | LMNA (0.34) | ALDH1A1LMNA | |
| SCHEMBL10358951 | 0.69 | SLC6A4 (0.45) | HTR1ASLC6A2SLC6A4CYP1A2CYP3A4 | |
| SCHEMBL1703057 | 0.69 | TAS1R3 (0.45) | HTR1ASLC6A2SLC6A4TAAR1ALDH1A1 | |
| SCHEMBL4079547 | 0.69 | SCN5A (0.37) | SLC6A4CYP1A2CYP3A4CYP2D6NFKB1 | |
| Hydrochloric Acid SCHEMBL7484049 | 0.67 | LMNA (0.37) | SLC6A2SLC6A4CYP1A2CYP3A4CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2066673-A2 | TRICYCLIC COMPOUNDS AND ITS USE AS TYROSINE KINASE MODULATORS | ChemBridge Research Laboratories, Inc. (US) | 2009-06-10 | — | — | EP | disclosed |
| WO-2008021369-A2 | TRICYCLIC COMPOUNDS AND ITS USE AS TYROSINE KINASE MODULATORS | CHEMBRIDGE RESEARCH LABORATORIES, INC. (US) | 2008-02-21 | — | — | WO | disclosed |