Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.55 |
| ▸ | GAA | P10253 | 1/20 | 0.55 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | HPGD | P15428 | 4/20 | 0.48 |
| ▸ | NPC1 | O15118 | 2/20 | 0.47 |
| ▸ | RAB9A | P51151 | 2/20 | 0.47 |
| ▸ | P2RX7 | Q99572 | 2/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4070760 | 0.80 | RAB9A (0.64) | KMT2AEPHX2ALDH1A1MEN1HPGD | |
| SCHEMBL4067616 | 0.80 | P2RX7 (0.54) | KMT2AGAAALDH1A1HPGDNPC1 | |
| SCHEMBL4064577 | 0.74 | KMT2A (0.64) | KMT2AGAAALDH1A1MEN1HPGD | |
| SCHEMBL5082541 | 0.73 | KMT2A (0.67) | KMT2AGAAALDH1A1MEN1HPGD | |
| SCHEMBL4069435 | 0.73 | EPHX2 (0.60) | KMT2AGAAEPHX2MEN1HPGD | |
| SCHEMBL5071517 | 0.72 | P2RX7 (0.59) | KMT2AGAAEPHX2ALDH1A1HPGD | |
| SCHEMBL9113884 | 0.71 | KMT2A (1.00) | KMT2AGAAALDH1A1MEN1HPGD | |
| SCHEMBL9113880 | 0.71 | KMT2A (1.00) | KMT2AGAAALDH1A1MEN1HPGD | |
| Formic Acid SCHEMBL5085564 | 0.70 | P2RX7 (0.54) | KMT2AGAAEPHX2ALDH1A1HPGD | |
| SCHEMBL24576210 | 0.70 | ALDH1A1 (0.68) | KMT2AGAAALDH1A1MEN1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1415986-B1 | SPIRO ISOBENZOFURANES AS NEUROPEPTIDE Y RECEPTOR ANTAGONISTS | BANYU PHARMA CO LTD (JP) | 2009-04-08 | — | — | EP | disclosed |
| US-7205417-B2 | Spiro compounds | BANYU PHARMACEUTICAL CO., LTD. (JP) | 2007-04-17 | — | — | US | disclosed |