Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX2 | P34913 | 3/20 | 0.60 |
| ▸ | EPHX1 | P07099 | 2/20 | 0.57 |
| ▸ | HPGD | P15428 | 2/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.50 |
| ▸ | RAB9A | P51151 | 2/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | KLK7 | P49862 | 2/20 | 0.47 |
| ▸ | ATM | Q13315 | 1/20 | 0.47 |
| ▸ | TGM2 | P21980 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 2/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | HTR1E | P28566 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4070760 | 0.80 | RAB9A (0.64) | EPHX2EPHX1HPGDSMN1; SMN2RAB9A | |
| SCHEMBL4067616 | 0.80 | P2RX7 (0.54) | HPGDRAB9AGAAMAPTKMT2A | |
| SCHEMBL3822162 | 0.76 | EPHX2 (1.00) | EPHX2EPHX1HPGDSMN1; SMN2RAB9A | |
| SCHEMBL4866294 | 0.73 | EPHX2 (0.97) | EPHX2EPHX1HPGDSMN1; SMN2RAB9A | |
| SCHEMBL23431981 | 0.73 | EPHX1 (1.00) | EPHX2EPHX1HPGDSMN1; SMN2RAB9A | |
| SCHEMBL4069437 | 0.73 | EPHX2 (0.71) | EPHX2EPHX1HPGDSMN1; SMN2RAB9A | |
| SCHEMBL29086702 | 0.73 | EPHX2 (0.71) | EPHX2EPHX1HPGDSMN1; SMN2RAB9A | |
| SCHEMBL12196136 | 0.73 | EPHX1 (1.00) | EPHX2EPHX1HPGDSMN1; SMN2RAB9A | |
| SCHEMBL23432014 | 0.73 | EPHX1 (1.00) | EPHX2EPHX1HPGDSMN1; SMN2RAB9A | |
| SCHEMBL4073984 | 0.73 | KMT2A (0.55) | EPHX2HPGDRAB9APOLBGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1415986-B1 | SPIRO ISOBENZOFURANES AS NEUROPEPTIDE Y RECEPTOR ANTAGONISTS | BANYU PHARMA CO LTD (JP) | 2009-04-08 | — | — | EP | disclosed |
| US-7205417-B2 | Spiro compounds | BANYU PHARMACEUTICAL CO., LTD. (JP) | 2007-04-17 | — | — | US | disclosed |