Sugi Predict

Sugi Predict / Compounds / SCHEMBL5082541

SCHEMBL5082541

SCHEMBL5082541

C=CC(=O)NCc1ccccc1C

nearest known ligand 0.67

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
▸ KMT2A Q03164 3/20 0.67
▸ GAA P10253 2/20 0.67
▸ ALDH1A1 P00352 4/20 0.58
▸ HPGD P15428 3/20 0.58
▸ HTT P42858 1/20 0.54
▸ KDM4E B2RXH2 2/20 0.53
▸ LMNA P02545 3/20 0.50
▸ NPC1 O15118 2/20 0.50
▸ RAB9A P51151 2/20 0.50
▸ MEN1 O00255 2/20 0.49
▸ SMN1; SMN2 Q16637 2/20 0.49
▸ POLB P06746 1/20 0.49
▸ L3MBTL1 Q9Y468 1/20 0.49
▸ PKM P14618 1/20 0.49
▸ CA2 P00918 1/20 0.48
▸ TGM2 P21980 1/20 0.47
▸ MAPT P10636 1/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL59858 0.87 TGM2 (0.55) KMT2AGAAALDH1A1HPGDLMNA
SCHEMBL8765952 0.87 GAA (0.51) KMT2AGAAALDH1A1HPGDHTT
SCHEMBL9482489 0.83 KMT2A (0.48) KMT2AGAAALDH1A1HPGDHTT
SCHEMBL410698 0.81 TSHR (0.52) KMT2AGAAALDH1A1KDM4EPKM
SCHEMBL2449430 0.81 TGM2 (0.53) KMT2AGAAALDH1A1HPGDLMNA
SCHEMBL24112688 0.80 TGM2 (0.45) KMT2AGAAALDH1A1HPGDKDM4E
SCHEMBL5082960 0.80 NPC1 (0.55) KMT2AGAAALDH1A1HPGDKDM4E
SCHEMBL9113884 0.80 KMT2A (1.00) KMT2AGAAALDH1A1HPGDHTT
SCHEMBL16634646 0.80 TGM2 (0.45) KMT2AGAAALDH1A1HPGDHTT
SCHEMBL9113880 0.80 KMT2A (1.00) KMT2AGAAALDH1A1HPGDHTT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 30 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20210369731-A1 COVALENT TARGETING OF E3 LIGASES THE REGENTS OF THE UNIVERSITY OF CALIFORNIA 2021-12-02 — — US disclosed
US-20200062696-A1 COMPOSITIONS AND METHODS FOR INHIBITING RETICULON 4 THE REGENTS OF THE UNIVERSITY OF CALIFORNIA 2020-02-27 — — US disclosed
US-20200062696-A1 COMPOSITIONS AND METHODS FOR INHIBITING RETICULON 4 THE REGENTS OF THE UNIVERSITY OF CALIFORNIA 2020-02-27 — — US disclosed
US-20200054651-A1 COMPOSITIONS AND METHODS FOR MODULATING PPP2R1A THE REGENTS OF THE UNIVERSITY OF CALIFORNIA 2020-02-20 — — US disclosed
US-20200054651-A1 COMPOSITIONS AND METHODS FOR MODULATING PPP2R1A THE REGENTS OF THE UNIVERSITY OF CALIFORNIA 2020-02-20 — — US disclosed
CN-110785426-A Compositions and methods for modulating PPP2R1A 加利福尼亚大学董事会 2020-02-11 — — CN disclosed
CN-110461322-A For inhibiting the composition and method of plasma membrane protein 4 UNIV CALIFORNIA 2019-11-15 — — CN disclosed
US-20190290778-A1 METHODS AND COMPOUNDS FOR TARGETED AUTOPHAGY FRONTIER MEDICINES CORPORATION 2019-09-26 — — US disclosed
CN-110088209-A Bedded substance contains liquid and its manufacturing method 株式会社ADEKA 2019-08-02 — — CN disclosed
WO-2018144870-A1 COMPOSITIONS AND METHODS FOR INHIBITING RETICULON 4 THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2018-08-09 — — WO disclosed
CN-102834264-B Method for making lithographic printing plate FUJIFILM CORP 2015-03-25 — — CN disclosed
US-20080177002-A1 Thermoplastic Resin Composition, Optical Film, And Process For Producing Film JSR CORPORATION (JP) 2008-07-24 — — US disclosed
EP-1837374-A1 THERMOPLASTIC RESIN COMPOSITION, OPTICAL FILM, AND PROCESS FOR PRODUCING FILM JSR Corporation (JP) 2007-09-26 — — EP disclosed
CN-1422743-A Driginal plate of plate-printing board FUJI PHOTO FILM CO LTD (JP) 2003-06-11 — — CN disclosed
US-5998091-A COPOLYMER OF A MONOFUNCTIONAL MACROMONOMER HAVING A PARTICULAR POLYMERIZABLE DOUBLE BOND-CONTAINING GROUP SITUATED AT ONLY ONE END OF THE MAIN CHAIN, A QUATERNARY AMMONIUM SALT AND AN AMIDE FUJI PHOTO FILM CO., LTD. (JP) 1999-12-07 — — US disclosed
EP-0505972-B1 Process for producing styrenic copolymer IDEMITSU KOSAN CO (JP) 1997-06-11 — — EP disclosed
EP-0490269-B1 Graft copolymer and process for producing the same IDEMITSU KOSAN CO (JP) 1996-02-28 — — EP disclosed
US-5250629-A Graft polymerization of styrene and ethylenically unsaturated monomer using transition metal catalysts, organoaluminum compounds; films, packaging, automobile parts IDEMITSU KOSAN CO., LTD. (JP) 1993-10-05 — — US disclosed
EP-0505972-A2 Process for producing styrenic copolymer IDEMITSU KOSAN COMPANY LIMITED (JP) 1992-09-30 — — EP disclosed
EP-0490269-A1 Graft copolymer and process for producing the same IDEMITSU KOSAN COMPANY LIMITED (JP) 1992-06-17 — — EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20200062696-A1 COMPOSITIONS AND METHODS FOR INHIBITING RETICULON 4 RTN4, RTN3, RCN1 KMT2A 4610/4885GAA 2186/4885ALDH1A1 4014/4885
US-20190290778-A1 METHODS AND COMPOUNDS FOR TARGETED AUTOPHAGY ATG7, BECN1, SQSTM1 KMT2A 3168/4885GAA 148/4885ALDH1A1 4188/4885
US-20210369731-A1 COVALENT TARGETING OF E3 LIGASES RNF114, RNF4, RNF168 KMT2A 501/4885GAA 2314/4885ALDH1A1 2969/4885
US-20200054651-A1 COMPOSITIONS AND METHODS FOR MODULATING PPP2R1A PPP2R1A, PPP3CA, PPP2R2A KMT2A 2573/4885GAA 3554/4885ALDH1A1 2930/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.