Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 3/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | ENTPD1 | P49961 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 2/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | ENPP2 | Q13822 | 4/20 | 0.35 |
| ▸ | ATF4 | P18848 | 1/20 | 0.35 |
| ▸ | DGAT2 | Q96PD7 | 1/20 | 0.35 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.35 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.35 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | F10 | P00742 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4081068 | 0.91 | THRB (0.39) | MEN1KMT2AENTPD1HPGDALDH1A1 | |
| SCHEMBL206649 | 0.88 | ENPP2 (0.44) | MEN1KMT2ALMNAHPGDSMN1; SMN2 | |
| SCHEMBL4074159 | 0.87 | SSTR4 (0.39) | MEN1KMT2AENTPD1SMN1; SMN2ALDH1A1 | |
| SCHEMBL207874 | 0.84 | KMT2A (0.55) | MEN1KMT2ALMNAHPGDSMN1; SMN2 | |
| SCHEMBL5160624 | 0.84 | LMNA (0.43) | MEN1KMT2ALMNAHPGDSMN1; SMN2 | |
| SCHEMBL207100 | 0.81 | NPSR1 (0.43) | MEN1KMT2ALMNAHPGDSMN1; SMN2 | |
| Butane SCHEMBL4074088 | 0.80 | MEN1 (0.38) | MEN1KMT2ALMNAHPGDSMN1; SMN2 | |
| SCHEMBL205569 | 0.79 | ENPP2 (0.46) | MEN1KMT2AHPGDALDH1A1ENPP2 | |
| SCHEMBL206987 | 0.79 | POLB (0.56) | MEN1KMT2ALMNAHPGDMAPT | |
| SCHEMBL206932 | 0.78 | LMNA (0.46) | MEN1KMT2ALMNAHPGDSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1745010-B1 | SUBSTITUTED CYCLOHEXYL-1,4-DIAMINE DERIVATIVES | GRUENENTHAL GMBH (DE) | 2009-08-05 | — | — | EP | claimed |
| EP-1745010-B1 | SUBSTITUTED CYCLOHEXYL-1,4-DIAMINE DERIVATIVES | GRUENENTHAL GMBH (DE) | 2009-08-05 | — | — | EP | disclosed |