Sugi Predict

Sugi Predict / Compounds / SCHEMBL407413

SCHEMBL407413

SCHEMBL407413

NS(=O)(=O)c1ccccc1Cc1ccccc1

nearest known ligand 0.57

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
▸ CA2 P00918 11/20 0.50
▸ CA1 P00915 10/20 0.50
▸ CA9 Q16790 8/20 0.50
▸ CA12 O43570 5/20 0.50
▸ CA14 Q9ULX7 3/20 0.50
▸ BCL2 P10415 1/20 0.50
▸ BCL2L1 Q07817 1/20 0.50
▸ HTR2A P28223 1/20 0.47
▸ CA6 P23280 3/20 0.47
▸ CA5A P35218 3/20 0.47
▸ CA4 P22748 2/20 0.47
▸ CA7 P43166 2/20 0.47
▸ CA5B Q9Y2D0 2/20 0.47
▸ CYP2C9 P11712 1/20 0.47
▸ PTGES2 Q9H7Z7 2/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30988956 1.00 CA2 (0.50) CA2CA1CA9CA12CA14
Methane SCHEMBL28850761 0.98 CA2 (0.49) CA2CA1CA9CA12CA14
Hydrochloric Acid SCHEMBL3517386 0.98 CA1 (0.49) CA2CA1CA9CA12CA14
SCHEMBL4662843 0.85 PTGES2 (0.54) CA2CA1CA9CA12CA14
SCHEMBL4664432 0.85 CA1 (0.42) CA2CA1CA9CA12CA14
SCHEMBL6121437 0.85 CA1 (0.45) CA2CA1CA9CA12CA14
SCHEMBL4662891 0.85 CA2 (0.47) CA2CA1CA9CA12CA14
SCHEMBL4183580 0.85 CA1 (0.45) CA2CA1CA9CA12CA14
SCHEMBL4662818 0.85 CA2 (0.47) CA2CA1CA9CA12CA14
SCHEMBL4663042 0.85 KCNA5 (0.43) CA2CA1CA9CA12CA14

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 66 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-108409612-A A kind of method that N- benzyl benzenesulfonamides are catalyzed and synthesized by boric acid/Catalyzed by Oxalic Acid system under microwave radiation 福建医科大学 2018-08-17 — — CN claimed
US-20080166359-A1 Methods of using MEK inhibitors EXELIXIS, INC. 2008-07-10 — — US claimed
EP-4716529-A2 COMPOUNDS THAT RE-ACTIVATE MUTANT P53 Institute For Cancer Research d/b/a The Research Institute of Fox Chase Cancer Center (US) 2026-04-01 — — EP disclosed
WO-2024243343-A2 COMPOUNDS THAT RE-ACTIVATE MUTANT P53 KARANICOLAS JOHN (US) 2024-11-28 — — WO disclosed
US-11339122-B2 hTRPV1 chemical agents University of Pittsburgh—of the Commonwealth System of Higher Education (US) 2022-05-24 — — US disclosed
US-11124482-B2 C-met modulators and methods of use EXELIXIS, INC. (US) 2021-09-21 — — US disclosed
US-20210253530-A9 C-MET MODULATORS AND METHODS OF USE EXELIXIS, INC. 2021-08-19 — — US disclosed
US-20210171454-A1 hTRPV1 CHEMICAL AGENTS UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (US) 2021-06-10 — — US disclosed
US-10899702-B2 HTRPVI chemical agents University of Pittsburgh—of the Commonwealth System of Higher Education (US) 2021-01-26 — — US disclosed
US-20200331860-A1 C-Met Modulators and Methods of Use EXELIXIS INC (US) 2020-10-22 — — US disclosed
CN-107739322-B Synthetic method of sulfonamide compound 济南大学 2020-06-23 — — CN disclosed
WO-2000047568-A2 1,2-BENZOTHIAZEPINES FOR THE TREATMENT OF HYPERLIPIDEMIC DISEASES G.D. SEARLE LLC (US) 2000-08-17 — — WO disclosed
EP-0468971-A1 NOVEL BENZIMIDAZOLE DERIVATIVES BRITISH BIO-TECHNOLOGY LIMITED (GB) 1992-02-05 — — EP disclosed
US-4629810-A HERBICIDES CIBA-GEIGY CORPORATION (US) 1986-12-16 — — US disclosed
US-4510325-A Phenyl sulfonamides CIBA-GEIGY CORPORATION (US) 1985-04-09 — — US disclosed
US-4479821-A HERBICIDES, PLANT GROWTH REGULATORS CIBA-GEIGY CORPORATION (US) 1984-10-30 — — US disclosed
US-4468245-A N-(2,3-Epoxypropylene)-n-aralkylsulfonamide and herbicidal compositions containing the same MITSUBISHI CHEMICAL INDUSTRIES LTD. (JP) 1984-08-28 — — US disclosed
US-4443245-A HERBICIDES, PLANT GROWTH REGULATORS CIBA-GEIGY CORPORATION (US) 1984-04-17 — — US disclosed
US-4425154-A HERBICIDES, PLANT GROWTH REGULATORS CIBA-GEIGY CORPORATION (US) 1984-01-10 — — US disclosed
US-4419121-A HERBICIDES CIBA-GEIGY CORPORATION (US) 1983-12-06 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20200331860-A1 C-Met Modulators and Methods of Use FLT4, FLT1, MET CA2 1724/4885CA1 3329/4885CA9 1962/4885
US-10899702-B2 HTRPVI chemical agents TRPV1, TRPA1, TRPV3 CA2 639/4885CA1 2144/4885CA9 3186/4885
US-20210171454-A1 hTRPV1 CHEMICAL AGENTS TRPV1, TRPA1, TRPV4 CA2 680/4885CA1 2152/4885CA9 3490/4885
US-20210253530-A9 C-MET MODULATORS AND METHODS OF USE FLT4, FLT1, MET CA2 1724/4885CA1 3329/4885CA9 1962/4885
US-20080166359-A1 Methods of using MEK inhibitors BRAF, NRAS, KRAS CA2 735/4885CA1 1855/4885CA9 750/4885
US-11124482-B2 C-met modulators and methods of use FLT4, FLT1, MET CA2 1724/4885CA1 3329/4885CA9 1962/4885
US-11339122-B2 hTRPV1 chemical agents TRPV1, TRPA1, TRPV4 CA2 726/4885CA1 2251/4885CA9 3519/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.