Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.48 |
| ▸ | VCP | P55072 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.46 |
| ▸ | MAPT | P10636 | 4/20 | 0.46 |
| ▸ | MEN1 | O00255 | 3/20 | 0.46 |
| ▸ | GAA | P10253 | 3/20 | 0.46 |
| ▸ | HTT | P42858 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | MRE11 | P49959 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | SIRT5 | Q9NXA8 | 1/20 | 0.42 |
| ▸ | ATM | Q13315 | 1/20 | 0.41 |
| ▸ | MAOA | P21397 | 4/20 | 0.41 |
| ▸ | MAOB | P27338 | 4/20 | 0.41 |
| ▸ | KCNQ1 | P51787 | 1/20 | 0.41 |
| ▸ | CFTR | P13569 | 1/20 | 0.40 |
| ▸ | PARP1 | P09874 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4078495 | 0.89 | KDM4E (0.51) | KDM4EVCPKMT2AMAPTMEN1 | |
| SCHEMBL3166865 | 0.75 | MAOA (0.54) | KDM4EVCPKMT2AMAPTMEN1 | |
| SCHEMBL3175801 | 0.75 | VCP (0.58) | KDM4EVCPKMT2AMAPTMEN1 | |
| SCHEMBL27698166 | 0.73 | VCP (0.49) | KDM4EVCPKMT2AMAPTMEN1 | |
| SCHEMBL9250823 | 0.72 | CDC25A (0.52) | KDM4EVCPKMT2AMAPTMEN1 | |
| SCHEMBL3525480 | 0.72 | KDM4E (0.53) | KDM4EVCPKMT2AMAPTMEN1 | |
| SCHEMBL5381785 | 0.72 | VCP (0.55) | KDM4EVCPKMT2AMAPTMEN1 | |
| SCHEMBL4088247 | 0.72 | KDM4E (0.53) | KDM4EVCPKMT2AMAPTMEN1 | |
| SCHEMBL4088254 | 0.72 | KDM4E (0.53) | KDM4EVCPKMT2AMAPTMEN1 | |
| SCHEMBL8824039 | 0.71 | ITGB3 (0.58) | KDM4EKMT2AMAPTMEN1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2054410-A2 | OXAZOLIDONE DERIVATIVES AS PR MODULATORS | Wyeth (US) | 2009-05-06 | — | — | EP | disclosed |
| WO-2008021331-A2 | OXAZOLIDONE DERIVATIVES AS PR MODULATORS | WYETH (US) | 2008-02-21 | — | — | WO | disclosed |
| WO-2008021339-A2 | PYRROLIDINE AND RELATED DERIVATIVES USEFUL AS PR MODULATORS | WYETH (US) | 2008-02-21 | — | — | WO | disclosed |