Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 8/20 | 0.81 |
| ▸ | ALOX5 | P09917 | 6/20 | 0.81 |
| ▸ | MAPK13 | O15264 | 6/20 | 0.81 |
| ▸ | MAPK12 | P53778 | 6/20 | 0.81 |
| ▸ | MAPK11 | Q15759 | 6/20 | 0.81 |
| ▸ | GCGR | P47871 | 5/20 | 0.81 |
| ▸ | RAF1 | P04049 | 2/20 | 0.65 |
| ▸ | MAPT | P10636 | 4/20 | 0.64 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.64 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.64 |
| ▸ | HPGD | P15428 | 4/20 | 0.64 |
| ▸ | CSNK1D | P48730 | 3/20 | 0.64 |
| ▸ | PRKD3 | O94806 | 2/20 | 0.64 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.64 |
| ▸ | FRK | P42685 | 2/20 | 0.64 |
| ▸ | MAPK9 | P45984 | 2/20 | 0.64 |
| ▸ | CSNK1A1 | P48729 | 2/20 | 0.64 |
| ▸ | GSK3B | P49841 | 2/20 | 0.64 |
| ▸ | PTK6 | Q13882 | 2/20 | 0.64 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.64 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2649978 | 0.89 | MAPK14 (1.00) | MAPK14ALOX5MAPK13MAPK12MAPK11 | |
| SCHEMBL19868985 | 0.85 | MAPK13 (0.79) | MAPK14ALOX5MAPK13MAPK12MAPK11 | |
| SCHEMBL19869007 | 0.85 | ALOX5 (0.72) | MAPK14ALOX5MAPK13MAPK12MAPK11 | |
| SCHEMBL4552086 | 0.84 | RAF1 (0.88) | MAPK14ALOX5MAPK13MAPK12MAPK11 | |
| SCHEMBL4074387 | 0.81 | TGFBR1 (0.77) | MAPK14ALOX5MAPK13MAPK12MAPK11 | |
| SCHEMBL8797140 | 0.81 | RAF1 (0.67) | MAPK14ALOX5MAPK13MAPK12MAPK11 | |
| SCHEMBL28904610 | 0.79 | MAPK13 (0.87) | MAPK14ALOX5MAPK13MAPK12MAPK11 | |
| Sb-202190 SCHEMBL3386753 | 0.78 | MAPK13 (1.00) | MAPK14ALOX5MAPK13MAPK12MAPK11 | |
| SCHEMBL19868954 | 0.78 | MAPK14 (0.75) | MAPK14ALOX5MAPK13MAPK12MAPK11 | |
| SCHEMBL9195650 | 0.78 | MAPK13 (1.00) | MAPK14ALOX5MAPK13MAPK12MAPK11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180044316-A1 | POTENTIATORS OF BETA-LACTAM ANTIBIOTICS | UNIVERSITY OF NOTRE DAME DU LAC (US) | 2018-02-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180044316-A1 | POTENTIATORS OF BETA-LACTAM ANTIBIOTICS | CREB1, PPP6R1, PPP1R10 | MAPK14 440/4885ALOX5 4789/4885MAPK13 782/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.