Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN3A | Q9NY46 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 3/20 | 0.40 |
| ▸ | THRB | P10828 | 1/20 | 0.40 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.40 |
| ▸ | MAOB | P27338 | 1/20 | 0.40 |
| ▸ | PARP15 | Q460N3 | 1/20 | 0.40 |
| ▸ | PARP14 | Q460N5 | 1/20 | 0.40 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.40 |
| ▸ | DPP4 | P27487 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | RARB | P10826 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4487434 | 0.87 | SMN1; SMN2 (0.50) | ALDH1A1HDAC1HPGDRARBSMN1; SMN2 | |
| SCHEMBL4486859 | 0.83 | OPRM1 (0.52) | CHEK2MAOBPARP10 | |
| SCHEMBL13335597 | 0.81 | DPP4 (0.50) | SCN3ADPP4ALDH1A1HDAC1KDM4E | |
| Hydrochloric Acid SCHEMBL3340923 | 0.81 | DPP4 (0.49) | SCN3ADPP4ALDH1A1HDAC1KDM4E | |
| SCHEMBL4074968 | 0.80 | OPRM1 (0.60) | MAPTALDH1A1MEN1KMT2AHDAC1 | |
| SCHEMBL4074391 | 0.79 | HDAC1 (0.56) | ALDH1A1HDAC1 | |
| SCHEMBL4081861 | 0.78 | OPRM1 (0.53) | HDAC1RARBKDM4ESMN1; SMN2 | |
| SCHEMBL4075498 | 0.77 | OPRM1 (0.43) | HDAC1RARB | |
| SCHEMBL4498120 | 0.76 | HDAC1 (0.53) | PARP10MEN1KMT2AHDAC1KDM4E | |
| SCHEMBL4073644 | 0.76 | OPRM1 (0.53) | DPP4HDAC1RARBSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7615651-B2 | Diaryl, dipyridinyl and aryl-pyridinyl derivatives and uses thereof | PFIZER INC. (US) | 2009-11-10 | — | — | US | claimed |
| EP-2084127-A1 | DIARYL, DIPYRIDINYL AND ARYL-PYRIDINYL DERIVATIVES AND USES THEREOF | Pfizer Products Inc. (US) | 2009-08-05 | — | — | EP | claimed |
| WO-2008059335-A1 | DIARYL, DIPYRIDINYL AND ARYL-PYRIDINYL DERIVATIVES AND USES THEREOF | PFIZER PRODUCTS INC. (US) | 2008-05-22 | — | — | WO | claimed |