Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | MAOA | P21397 | 1/20 | 0.30 |
| ▸ | MAOB | P27338 | 1/20 | 0.30 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.30 |
| ▸ | FER | P16591 | 1/20 | 0.30 |
| ▸ | LTK | P29376 | 1/20 | 0.30 |
| ▸ | CDK8 | P49336 | 1/20 | 0.30 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.30 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.30 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL194389 | 0.68 | RAD52 (0.36) | GAAMAPT | |
| SCHEMBL3103996 | 0.68 | MEN1 (0.33) | MAPTMAOAMAOB | |
| SCHEMBL1383598 | 0.64 | MAOA (0.32) | MAOAMAOBPDGFRAFERLTK | |
| SCHEMBL131587 | 0.64 | GAA (0.37) | GAAMAPT | |
| SCHEMBL156862 | 0.62 | MAPT (0.41) | GAAMAPTMAOAMAOBPDGFRA | |
| SCHEMBL29353131 | 0.62 | MAPT (0.41) | GAAMAPTMAOAMAOBPDGFRA | |
| SCHEMBL1618358 | 0.61 | MAOA (0.42) | GAAMAPTMAOAMAOBPDGFRA | |
| SCHEMBL8780 | 0.61 | GAA (0.34) | GAAMAPTMAOAMAOBPDGFRA | |
| SCHEMBL207759 | 0.61 | GAA (0.44) | GAAMAPT | |
| SCHEMBL2514534 | 0.60 | LMNA (0.31) | GAAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7566707-B2 | Imidazopyridazinone and imidazopyridone derivatives, the preparation thereof and their use as pharmaceutical compositions | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2009-07-28 | — | — | US | claimed |