SCHEMBL131587

SCHEMBL131587

[C]1=Cc2ccccc2NN1

nearest known ligand 0.37

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
GAA P10253 1/20 0.37
MAPT P10636 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4074645 0.64 GAA (0.34) GAAMAPT
SCHEMBL194389 0.62 RAD52 (0.36) GAAMAPT
SCHEMBL4066430 0.62 NPC1 (0.32) MAPT
SCHEMBL1162619 0.62
SCHEMBL1162665 0.62 GAA (0.37) GAAMAPT
SCHEMBL290837 0.62
SCHEMBL1449815 0.60 GAA (0.36) GAAMAPT
SCHEMBL1449794 0.60 GAA (0.36) GAAMAPT
SCHEMBL18935280 0.60 GAA (0.36) GAAMAPT
SCHEMBL4577839 0.60 GAA (0.36) GAAMAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1350 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2022266458-A1 6-HETEROCYCLOALKYL-QUINAZOLINE DERIVATIVES AND USES THEREOF BLACK DIAMOND THERAPEUTICS, INC. (US) 2022-12-22 WO claimed
US-9078887-B2 Bicyclic heteroaryl inhibitors of PDE4 KALYPSYS, INC. (US) 2015-07-14 US claimed
US-12036231-B2 Cyclic dinucleotides as agonists of stimulator of interferon gene dependent signalling BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (US) 2024-07-16 US disclosed
CN-114026083-B Heterocyclic inhibitors of tyrosine kinases 德州大学系统董事会 2024-07-09 CN disclosed
EP-3774802-B1 COMPOUNDS AND METHODS FOR SELECTIVE PROTEOLYSIS OF GLUCOCORTICOID RECEPTORS UNIV TEXAS (US) 2024-07-03 EP disclosed
US-20240199554-A1 INHIBITORS OF RECEPTOR INTERACTING PROTEIN KINASE I FOR THE TREATMENT OF DISEASE BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM 2024-06-20 US disclosed
WO-2024124056-A1 NOVEL SULFOXIMINE ACTIVATORS OF SEROTONIN RECEPTORS ENTHEOGENIX BIOSCIENCES, INC. (US) 2024-06-13 WO disclosed
EP-3551625-B1 HETEROCYCLIC INHIBITORS OF MCT4 VETTORE LLC (US) 2024-06-12 EP disclosed
US-12006321-B2 Substituted pyrazolo[1,5-a]pyrimidines as apelin receptor agonists Sanford Burnham Prebys Medical Discovery Institute (US) 2024-06-11 US disclosed
US-11998606-B2 Compounds and methods for selective proteolysis of glucocorticoid receptors BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (US) 2024-06-04 US disclosed
EP-4373822-A2 COMPOSITIONS AND METHODS FOR INHIBITION OF RAS Theras Inc. (US) 2024-05-29 EP disclosed
EP-1463505-A2 3-(PHENYL-ALKOXY)-5-(PHENYL)-PYRIDINE DERIVATIVES AND RELATED COMPOUNDS AS KINASE INHIBITORS FOR THE TREATMENT OF CANCER Abbott Laboratories (US) 2004-10-06 EP disclosed
US-20040087585-A1 Peptide deformylase inhibitors GLAXOSMITHKLINE LLC 2004-05-06 US disclosed
WO-2003101442-A1 PEPTIDE DEFORMYLASE INHIBITORS SMITHKLINE BEECHAM CORPORATION (US) 2003-12-11 WO disclosed
EP-1363873-A2 PEPTIDE DEFORMYLASE INHIBITORS SmithKline Beecham Corporation (US) 2003-11-26 EP disclosed
US-20030199511-A1 Kinase inhibitors ABBVIE INC. 2003-10-23 US disclosed
US-20030187026-A1 Kinase inhibitors ABBOTT LABORATORIES 2003-10-02 US disclosed
WO-2003051366-A2 3-(PHENYL-ALKOXY)-5-(PHENYL)-PYRIDINE DERIVATIVES AND RELATED COMPOUNDS AS KINASE INHIBITORS FOR THE TREATMENT OF CANCER ABBOTT LABORATORIES (US) 2003-06-26 WO disclosed
WO-2002070541-A2 PEPTIDE DEFORMYLASE INHIBITORS SMITH KLINE BEECHAM CORPORATION (US) 2002-09-12 WO disclosed
EP-0382185-A2 Carbostyril derivatives OTSUKA PHARMACEUTICAL CO., LTD. (JP) 1990-08-16 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20030187026-A1 Kinase inhibitors MAP3K20, MAP3K19, MAP3K1 GAA 1861/4885MAPT 3336/4885
US-20040087585-A1 Peptide deformylase inhibitors PDF, DPEP1, PEPD GAA 1013/4885MAPT 3406/4885
US-12006321-B2 Substituted pyrazolo[1,5-a]pyrimidines as apelin receptor agonists APLNR, AP3B1, AGTR1 GAA 3898/4885MAPT 3809/4885
US-20030199511-A1 Kinase inhibitors MAP3K20, MAP3K19, MAP3K1 GAA 1861/4885MAPT 3336/4885
US-12036231-B2 Cyclic dinucleotides as agonists of stimulator of interferon gene dependent signalling STING1, IRF3, CGAS GAA 1021/4885MAPT 4863/4885
US-20240199554-A1 INHIBITORS OF RECEPTOR INTERACTING PROTEIN KINASE I FOR THE TREATMENT OF DISEASE RIPK1, RIPK2, RIPK4 GAA 2476/4885MAPT 577/4885
US-11998606-B2 Compounds and methods for selective proteolysis of glucocorticoid receptors NR3C1, NR3C2, GRK5 GAA 1160/4885MAPT 4569/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.