Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA2A | P08913 | 1/20 | 0.46 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.46 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.46 |
| ▸ | PPARG | P37231 | 2/20 | 0.46 |
| ▸ | SLC6A2 | P23975 | 3/20 | 0.37 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.37 |
| ▸ | RXRA | P19793 | 1/20 | 0.36 |
| ▸ | RXRB | P28702 | 1/20 | 0.36 |
| ▸ | RXRG | P48443 | 1/20 | 0.36 |
| ▸ | IDO1 | P14902 | 2/20 | 0.35 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.35 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.35 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.34 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.34 |
| ▸ | MAOB | P27338 | 1/20 | 0.34 |
| ▸ | HTR1A | P08908 | 1/20 | 0.34 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | SSTR4 | P31391 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9088449 | 0.85 | MAPT (0.42) | RXRARXRBRXRGSMN1; SMN2 | |
| SCHEMBL105728 | 0.78 | ADRA2A (0.53) | ADRA2AADRA2BADRA2CPPARGSLC6A2 | |
| SCHEMBL1116784 | 0.75 | PPARG (0.51) | ADRA2AADRA2BADRA2CPPARGRXRA | |
| SCHEMBL4071169 | 0.75 | ALOX15 (0.44) | ADRA2BSLC6A2SLC6A4SLC6A3HPGD | |
| SCHEMBL223516 | 0.75 | ADRA2A (0.50) | ADRA2AADRA2BADRA2CPPARGSLC6A2 | |
| SCHEMBL6256715 | 0.75 | KMT2A (0.53) | ADRA2AADRA2BADRA2CSMN1; SMN2 | |
| SCHEMBL16095022 | 0.75 | ADRA2A (0.47) | ADRA2AADRA2BADRA2CPPARGSLC6A2 | |
| SCHEMBL7913213 | 0.74 | ALDH1A1 (0.44) | ADRA2AADRA2BADRA2CSLC6A2SLC6A4 | |
| SCHEMBL4073503 | 0.74 | ADRA2A (0.42) | ADRA2AADRA2BADRA2CMAOBHTR1A | |
| SCHEMBL9780582 | 0.73 | PPARG (0.60) | ADRA2AADRA2BADRA2CPPARGRXRA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2066673-A2 | TRICYCLIC COMPOUNDS AND ITS USE AS TYROSINE KINASE MODULATORS | ChemBridge Research Laboratories, Inc. (US) | 2009-06-10 | — | — | EP | disclosed |
| WO-2008021369-A2 | TRICYCLIC COMPOUNDS AND ITS USE AS TYROSINE KINASE MODULATORS | CHEMBRIDGE RESEARCH LABORATORIES, INC. (US) | 2008-02-21 | — | — | WO | disclosed |