Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA2A | P08913 | 2/20 | 0.42 |
| ▸ | ADRA2C | P18825 | 2/20 | 0.42 |
| ▸ | HTR1A | P08908 | 1/20 | 0.42 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | ATM | Q13315 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.36 |
| ▸ | MAOA | P21397 | 1/20 | 0.36 |
| ▸ | MAOB | P27338 | 1/20 | 0.36 |
| ▸ | HTR7 | P34969 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.35 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17386433 | 0.80 | HTR1A (0.46) | ADRA2AADRA2CHTR1AADRA2BKMT2A | |
| SCHEMBL4071668 | 0.80 | FFAR1 (0.36) | KMT2AMEN1ALDH1A1 | |
| SCHEMBL4078217 | 0.80 | PKM (0.43) | KMT2AMEN1ATMSMN1; SMN2LMNA | |
| SCHEMBL4071169 | 0.79 | ALOX15 (0.44) | ADRA2BKMT2AMEN1SMN1; SMN2LMNA | |
| SCHEMBL6256715 | 0.79 | KMT2A (0.53) | ADRA2AADRA2CADRA2BKMT2ASMN1; SMN2 | |
| SCHEMBL7913213 | 0.78 | ALDH1A1 (0.44) | ADRA2AADRA2CHTR1AADRA2BKMT2A | |
| SCHEMBL4069876 | 0.77 | ABL1 (0.40) | KMT2AMEN1GAASMN1; SMN2LMNA | |
| SCHEMBL29637386 | 0.76 | ADRA2A (0.49) | ADRA2AADRA2CHTR1AADRA2BKMT2A | |
| SCHEMBL248866 | 0.76 | ADRA2A (0.49) | ADRA2AADRA2CHTR1AADRA2BKMT2A | |
| SCHEMBL7685092 | 0.76 | HTR1A (0.49) | ADRA2AADRA2CHTR1AADRA2BKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2066673-A2 | TRICYCLIC COMPOUNDS AND ITS USE AS TYROSINE KINASE MODULATORS | ChemBridge Research Laboratories, Inc. (US) | 2009-06-10 | — | — | EP | disclosed |
| WO-2008021369-A2 | TRICYCLIC COMPOUNDS AND ITS USE AS TYROSINE KINASE MODULATORS | CHEMBRIDGE RESEARCH LABORATORIES, INC. (US) | 2008-02-21 | — | — | WO | disclosed |