Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 2/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL206738 | 0.83 | TSHR (0.46) | KMT2APOLBHTTTP53ALDH1A1 | |
| SCHEMBL4048631 | 0.82 | KMT2A (0.51) | KMT2APOLBMEN1ALDH1A1NPC1 | |
| SCHEMBL4049886 | 0.80 | MAPT (0.45) | KMT2APOLBMEN1MAPTNPC1 | |
| SCHEMBL208660 | 0.79 | PLAAT3 (0.46) | TP53NPC1RAB9A | |
| SCHEMBL205373 | 0.79 | CCR2 (0.47) | ALDH1A1 | |
| SCHEMBL206456 | 0.79 | POLB (0.45) | KMT2APOLBHTTTP53ALDH1A1 | |
| SCHEMBL208300 | 0.78 | LMNA (0.50) | KMT2APOLBMEN1TP53ALDH1A1 | |
| SCHEMBL207975 | 0.78 | HPGD (0.43) | KMT2APOLBHTTMEN1ALDH1A1 | |
| SCHEMBL5162372 | 0.78 | RAB9A (0.43) | KMT2AMEN1ALDH1A1NPC1RAB9A | |
| SCHEMBL2983415 | 0.78 | MEN1 (0.45) | KMT2AMEN1ALDH1A1MAPTRAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1745010-B1 | SUBSTITUTED CYCLOHEXYL-1,4-DIAMINE DERIVATIVES | GRUENENTHAL GMBH (DE) | 2009-08-05 | — | — | EP | claimed |