Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA2A | P08913 | 2/20 | 0.60 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.60 |
| ▸ | HTR1A | P08908 | 1/20 | 0.60 |
| ▸ | DRD1 | P21728 | 1/20 | 0.60 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.60 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.60 |
| ▸ | DRD3 | P35462 | 1/20 | 0.60 |
| ▸ | CA2 | P00918 | 4/20 | 0.57 |
| ▸ | HTT | P42858 | 1/20 | 0.56 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.56 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.56 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.56 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.56 |
| ▸ | SCN1A | P35498 | 1/20 | 0.56 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.56 |
| ▸ | SCN3A | Q9NY46 | 1/20 | 0.56 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.55 |
| ▸ | POLB | P06746 | 1/20 | 0.53 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.53 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8186813 | 1.00 | ADRA2A (0.60) | ADRA2AADRA1AHTR1ADRD1TBXA2R | |
| SCHEMBL439092 | 1.00 | ADRA2A (0.60) | ADRA2AADRA1AHTR1ADRD1TBXA2R | |
| SCHEMBL31407451 | 1.00 | ADRA2A (0.60) | ADRA2AADRA1AHTR1ADRD1TBXA2R | |
| SCHEMBL29841237 | 1.00 | ADRA2A (0.60) | ADRA2AADRA1AHTR1ADRD1TBXA2R | |
| Hydrochloric Acid SCHEMBL783118 | 0.98 | ADRA2A (0.58) | ADRA2AADRA1AHTR1ADRD1TBXA2R | |
| Bromide SCHEMBL11489853 | 0.98 | ADRA2A (0.58) | ADRA2AADRA1AHTR1ADRD1TBXA2R | |
| SCHEMBL406531 | 0.85 | HTT (0.61) | ADRA2AADRA1AHTR1ADRD1TBXA2R | |
| Hydrochloric Acid SCHEMBL8179101 | 0.83 | HTT (0.59) | ADRA2AADRA1AHTR1ADRD1TBXA2R | |
| SCHEMBL568115 | 0.80 | ADRA2A (0.60) | ADRA2AADRA1AHTR1ADRD1TBXA2R | |
| SCHEMBL11484814 | 0.80 | ADRA2A (0.56) | ADRA2AADRA1AHTR1ADRD1TBXA2R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 613 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8557796-B2 | Substituted 1-oxa-2,8-diaza-spiro [4,5] dec-2-ene derivatives and related treatment methods | GRUENENTHAL GMBH (DE) | 2013-10-15 | — | — | US | claimed |
| CN-102503929-A | Synthesis method for guanoxan sulfate | SHANGHAI MODERN HASEN SHANGQIU PHARMACEUTICAL CO LTD | 2012-06-20 | — | — | CN | claimed |
| US-20120071539-A1 | COMPOUNDS AND METHODS FOR MODULATING THE SILENCING OF A POLYNUCLEOTIDE OF INTEREST | EMORY UNIVERSITY (US) | 2012-03-22 | — | — | US | claimed |
| US-7829568-B2 | Substituted 5,6,7,8-tetrahydroimidazo[1,2-a]pyridin-2-ylamine compounds and their use for producing drugs | GRUENENTHAL GMBH (DE) | 2010-11-09 | — | — | US | claimed |
| US-20100029654-A1 | CARDIOVASCULAR COMPOSITIONS AND USE OF THE SAME FOR THE TREATMENT OF ALZHEIMER'S DISEASE | MOUNT SINAI SCHOOL OF MEDICINE | 2010-02-04 | — | — | US | claimed |
| EP-1869038-B1 | SUBSTITUTED 5,6,7,8-TETRAHYDRO-IMIDAZO[1,2-A]PYRIDIN-2-YLAMINE COMPOUNDS AND THEIR USE FOR PRODUCING DRUGS | GRUENENTHAL GMBH (DE) | 2009-07-08 | — | — | EP | claimed |
| EP-2007385-A2 | CARDIOVASCULAR COMPOSITION AND USE THE SAME FOR THE TREATMENT OF ALZHEIMERS DISEASE | Mount Sinai School of Medicine (US) | 2008-12-31 | — | — | EP | claimed |
| US-20080300256-A1 | Substituted 5,6,7,8-Tetrahydroimidazo[1,2-a]pyridin-2-ylamine Compounds and Their Use for Producing Drugs | GRUENENTHAL GMBH (DE) | 2008-12-04 | — | — | US | claimed |
| EP-1619183-B1 | 1-amido-3-(2-hydroxyphenoxy)-2-propanol derivatives and a process for preparing 2-amidomethyl-1, 4-benzodioxane derivatives | DAISO CO LTD (JP) | 2008-10-01 | — | — | EP | claimed |
| US-7419986-B2 | Antidepressant azaheterocyclylmethyl derivatives of heterocycle-fused benzodioxans | WYETH (US) | 2008-09-02 | — | — | US | claimed |
| US-20040132714-A1 | Antidepressant azaheterocyclylmethyl derivatives of heterocycle-fused benzodioxans | WYETH | 2004-07-08 | — | — | US | claimed |
| WO-2004024730-A1 | ANTIDEPRESSANT AZAHETEROCYCLYLMETHYL DERIVATIVES OF HETEROCYCLE-FUSED BENZODIOXANS | WYETH (US) | 2004-03-25 | — | — | WO | claimed |
| US-20040048868-A1 | Benzimidazoles | AVENTISUB LLC | 2004-03-11 | — | — | US | claimed |
| WO-2003035065-A1 | BENZIMIDAZOLES AND ANALOGUES AND THEIR USE AS PROTEIN KINASES INHIBITORS | AVENTIS PHARMACEUTICALS INC (US) | 2003-05-01 | — | — | WO | claimed |
| EP-0587625-B1 | N-ARYLALKYLDERIVATIVES OF 2-AMINOMETHYL-2,3-DIHYDRO-1,4-BENZODIOXINE AND THE PROCESS OF PREPARATION THEREOF | VUFB AS (CZ) | 1997-04-02 | — | — | EP | claimed |
| US-5424456-A | N-arylalkylderivatives of 2-aminomethyl-2,3-dihydro-1,4-benzodioxine and the process of preparation thereof | VYZKUMNY USTAV PRO FARMACII A BIOCHEMII S.P. (CS) | 1995-06-13 | — | — | US | claimed |
| EP-0587625-A1 | N-ARYLALKYLDERIVATIVES OF 2-AMINOMETHYL-2,3-DIHYDRO-1,4-BENZODIOXINE AND THE PROCESS OF PREPARATION THEREOF. | VYZK USTAV FARM BIOCHEM SP (CS) | 1994-03-23 | — | — | EP | claimed |
| WO-1992021671-A1 | N-ARYLALKYLDERIVATIVES OF 2-AMINOMETHYL-2,3-DIHYDRO-1,4-BENZODIOXINE AND THE PROCESS OF PREPARATION THEREOF | VYZKUMNY USTAV PRO FARMACII A BIOCHEMII, S.P. (CS) | 1992-12-10 | — | — | WO | claimed |
| CN-1019390-B | GLUTARIMIDE ANTIANXIETY AND ARTIHYPERTENSIVE AGENTS | MERRELL DOW PHARMA (US) | 1992-12-09 | — | — | CN | claimed |
| CN-85106560-A | The preparation of glutarimide anxiety and antihypertensive drug | — | 1987-03-18 | — | — | CN | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040048868-A1 | Benzimidazoles | CDK9, BMX, CDKN1A | ADRA2A 4149/4885ADRA1A 2818/4885HTR1A 3283/4885 |
| US-20080300256-A1 | Substituted 5,6,7,8-Tetrahydroimidazo[1,2-a]pyridin-2-ylamine Compounds and Their Use for Producing Drugs | CYP3A7, CYP3A5, CYP2D6 | ADRA2A 32/4885ADRA1A 39/4885HTR1A 33/4885 |
| US-20120071539-A1 | COMPOUNDS AND METHODS FOR MODULATING THE SILENCING OF A POLYNUCLEOTIDE OF INTEREST | SNRPE, NSUN2, SNRPA | ADRA2A 4426/4885ADRA1A 4502/4885HTR1A 4274/4885 |
| US-20040132714-A1 | Antidepressant azaheterocyclylmethyl derivatives of heterocycle-fused benzodioxans | CYP19A1, CRH, CYP17A1 | ADRA2A 311/4885ADRA1A 182/4885HTR1A 64/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.