Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.49 |
| ▸ | TP53 | P04637 | 1/20 | 0.49 |
| ▸ | XDH | P47989 | 1/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | XBP1 | P17861 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | IGF1R | P08069 | 2/20 | 0.44 |
| ▸ | KDM1A | O60341 | 1/20 | 0.44 |
| ▸ | TTBK1 | Q5TCY1 | 1/20 | 0.44 |
| ▸ | TTBK2 | Q6IQ55 | 1/20 | 0.44 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.44 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.44 |
| ▸ | JAK2 | O60674 | 1/20 | 0.43 |
| ▸ | ZAP70 | P43403 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | SYK | P43405 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14547699 | 0.82 | XDH (0.54) | MAPTMAPK1TP53XDHGAA | |
| SCHEMBL4790518 | 0.75 | XDH (0.51) | MAPTTP53XDHSMN1; SMN2PDE3B | |
| SCHEMBL4382248 | 0.73 | TTBK1 (0.56) | MAPTMAPK1TP53KDM1ATTBK1 | |
| SCHEMBL16423097 | 0.73 | MAPK10 (0.49) | MAPTMAPK1TP53GAAXBP1 | |
| SCHEMBL4411964 | 0.72 | TTBK1 (0.49) | MAPTMAPK1TP53HTTIGF1R | |
| SCHEMBL4075886 | 0.71 | SYK (0.46) | MAPTMAPK1TP53XDHJAK2 | |
| SCHEMBL15640618 | 0.71 | CA12 (0.52) | JAK2KITFLT3PIK3CA | |
| SCHEMBL15127731 | 0.71 | IGF1R (0.67) | MAPTMAPK1TP53IGF1RTTBK1 | |
| SCHEMBL7980595 | 0.71 | MAPT (0.62) | MAPTMAPK1TP53GAAHTT | |
| SCHEMBL23712415 | 0.70 | MAPK10 (0.50) | MAPTMAPK1TP53XBP1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1948659-A1 | PYRROLOPYRIMIDINE DERIVATIVES AS SYK INHIBITORS | GLAXO GROUP LIMITED (GB) | 2008-07-30 | — | — | EP | disclosed |
| WO-2007042299-A1 | PYRROLOPYRIMIDINE DERIVATIVES AS SYK INHIBITORS | GLAXO GROUP LIMITED (GB) | 2007-04-19 | — | — | WO | disclosed |