Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.45 |
| ▸ | MAPT | P10636 | 6/20 | 0.45 |
| ▸ | LMNA | P02545 | 3/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | POLB | P06746 | 2/20 | 0.41 |
| ▸ | GAA | P10253 | 2/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.38 |
| ▸ | HPGD | P15428 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | ATM | Q13315 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | PKM | P14618 | 1/20 | 0.37 |
| ▸ | GFER | P55789 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | HDAC3 | O15379 | 3/20 | 0.36 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.36 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.35 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4075137 | 0.81 | MEN1 (0.43) | KDM4EALDH1A1MAPTLMNASMN1; SMN2 | |
| SCHEMBL27968518 | 0.73 | KDM4E (0.63) | KDM4EALDH1A1MAPTLMNASMN1; SMN2 | |
| SCHEMBL4079956 | 0.73 | MTNR1A (0.42) | KDM4EALDH1A1MAPTLMNASMN1; SMN2 | |
| SCHEMBL13697479 | 0.67 | KDM4E (0.69) | KDM4EALDH1A1MAPTLMNASMN1; SMN2 | |
| SCHEMBL27370614 | 0.67 | MAPT (0.51) | KDM4EALDH1A1MAPTLMNASMN1; SMN2 | |
| SCHEMBL1061505 | 0.66 | KDM4E (0.67) | KDM4EALDH1A1MAPTLMNASMN1; SMN2 | |
| SCHEMBL27825029 | 0.66 | ALDH1A1 (0.59) | KDM4EALDH1A1MAPTLMNASMN1; SMN2 | |
| SCHEMBL9240048 | 0.65 | ALDH1A1 (0.58) | KDM4EALDH1A1LMNASMN1; SMN2L3MBTL1 | |
| SCHEMBL22074021 | 0.63 | ALOX5 (0.46) | MAPTSMN1; SMN2GAAL3MBTL1MEN1 | |
| SCHEMBL6243452 | 0.62 | MAPT (1.00) | KDM4EALDH1A1MAPTLMNASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009155362-A1 | SMALL MOLECULE HEMATOPOIETIC GROWTH FACTOR MIMETIC COMPOUNDS AND THEIR USES | LIGAND PHARMACEUTICALS INC. (US) | 2009-12-23 | — | — | WO | disclosed |