Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 2/20 | 0.39 |
| ▸ | F10 | P00742 | 4/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | HDAC3 | O15379 | 3/20 | 0.37 |
| ▸ | HDAC4 | P56524 | 3/20 | 0.37 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.37 |
| ▸ | HDAC7 | Q8WUI4 | 3/20 | 0.37 |
| ▸ | HDAC2 | Q92769 | 3/20 | 0.37 |
| ▸ | HDAC10 | Q969S8 | 3/20 | 0.37 |
| ▸ | HDAC11 | Q96DB2 | 3/20 | 0.37 |
| ▸ | HDAC8 | Q9BY41 | 3/20 | 0.37 |
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.37 |
| ▸ | HDAC9 | Q9UKV0 | 3/20 | 0.37 |
| ▸ | HDAC5 | Q9UQL6 | 3/20 | 0.37 |
| ▸ | HTR3E | A5X5Y0 | 3/20 | 0.37 |
| ▸ | HTR3B | O95264 | 3/20 | 0.37 |
| ▸ | HTR3A | P46098 | 3/20 | 0.37 |
| ▸ | HTR3D | Q70Z44 | 3/20 | 0.37 |
| ▸ | HTR3C | Q8WXA8 | 3/20 | 0.37 |
| ▸ | HRH4 | Q9H3N8 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21516108 | 0.89 | PTGS1 (0.42) | GAAF10POLBHDAC3HDAC4 | |
| SCHEMBL21516106 | 0.86 | GAA (0.45) | GAAF10USP2MEN1ALDH1A1 | |
| SCHEMBL21942347 | 0.79 | HDAC3 (0.43) | F10POLBHDAC3HDAC4HDAC1 | |
| SCHEMBL5543916 | 0.77 | HTR3A (0.41) | POLBHTR3EHTR3BHTR3AHTR3D | |
| SCHEMBL21516782 | 0.77 | F10 (0.42) | F10POLBHTR3EHTR3BHTR3A | |
| SCHEMBL3734963 | 0.77 | F10 (0.48) | F10POLBHTR3EHTR3BHTR3A | |
| SCHEMBL3732428 | 0.77 | POLB (0.46) | F10POLBHDAC3HDAC4HDAC1 | |
| SCHEMBL4069418 | 0.76 | F10 (0.50) | F10POLBHTR3EHTR3BHTR3A | |
| SCHEMBL21516088 | 0.74 | HTR3B (0.40) | F10POLBHTR3EHTR3BHTR3A | |
| SCHEMBL10242648 | 0.73 | GAA (0.66) | GAAPOLBMEN1ALDH1A1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1799671-A4 | CHEMICAL COMPOUNDS | SMITHKLINE BEECHAM CORP (US) | 2009-06-10 | — | — | EP | disclosed |
| EP-1784185-A4 | CHEMICAL COMPOUNDS | SMITHKLINE BEECHAM CORP (US) | 2009-06-03 | — | — | EP | disclosed |
| US-20070254910-A1 | CHEMICAL COMPOUNDS | SMITHKLINE BEECHAM CORPORATION | 2007-11-01 | — | — | US | disclosed |
| US-20070232615-A1 | Chemical Compounds | SMITHKLINE BEECHAM CORPORATION | 2007-10-04 | — | — | US | disclosed |
| EP-1799671-A2 | CHEMICAL COMPOUNDS | SmithKline Beecham Corporation (US) | 2007-06-27 | — | — | EP | disclosed |
| EP-1784185-A2 | CHEMICAL COMPOUNDS | SmithKline Beecham Corporation (US) | 2007-05-16 | — | — | EP | disclosed |
| WO-2006028896-A2 | CHEMICAL COMPOUNDS | SMITHKLINE BEECHAM CORPORATION (US) | 2006-03-16 | — | — | WO | disclosed |
| WO-2006026703-A2 | CHEMICAL COMPOUNDS | SMITHKLINE BEECHAM CORPORATION (US) | 2006-03-09 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070232615-A1 | Chemical Compounds | CXCR4, CCR5, CXCR3 | GAA 4011/4885F10 4041/4885POLB 3977/4885 |
| US-20070254910-A1 | CHEMICAL COMPOUNDS | CXCR4, CCR5, CXCR3 | GAA 4011/4885F10 4041/4885POLB 3977/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.