Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Floxuridine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.68 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.68 |
| ▸ | TK1 | P04183 | 3/20 | 0.52 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.52 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.52 |
| ▸ | TK2 | O00142 | 1/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | BLM | P54132 | 1/20 | 0.48 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Doxribtimine SCHEMBL28210016 | 0.90 | TK1 (0.52) | LMNASMN1; SMN2TK1TK2TSHR | |
| Deoxyuridine SCHEMBL28056346 | 0.84 | DUT (0.47) | LMNASMN1; SMN2TK1ALOX12ADRA1A | |
| Cytarabine SCHEMBL8144526 | 0.83 | LMNA (0.47) | LMNASMN1; SMN2TK1ALOX12ADRA1A | |
| Floxuridine SCHEMBL6270910 | 0.83 | LMNA (1.00) | LMNASMN1; SMN2TK1ALOX12ADRA1A | |
| Floxuridine SCHEMBL11564431 | 0.83 | LMNA (1.00) | LMNASMN1; SMN2TK1ALOX12ADRA1A | |
| Floxuridine SCHEMBL9155703 | 0.83 | LMNA (1.00) | LMNASMN1; SMN2TK1ALOX12ADRA1A | |
| Floxuridine SCHEMBL18573179 | 0.83 | LMNA (1.00) | LMNASMN1; SMN2TK1ALOX12ADRA1A | |
| Floxuridine SCHEMBL13674187 | 0.83 | LMNA (1.00) | LMNASMN1; SMN2TK1ALOX12ADRA1A | |
| Floxuridine SCHEMBL11563300 | 0.83 | LMNA (1.00) | LMNASMN1; SMN2TK1ALOX12ADRA1A | |
| Floxuridine SCHEMBL2050487 | 0.83 | LMNA (1.00) | LMNASMN1; SMN2TK1ALOX12ADRA1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 193 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8298277-B2 | Medical appliance optical delivery and deployment apparatus and method | MERIT MEDICAL SYSTEMS, INC. (US) | 2012-10-30 | — | — | US | claimed |
| EP-1424960-B1 | REMOVABLE STENT | MERIT MEDICAL SYSTEMS INC (US) | 2010-04-21 | — | — | EP | claimed |
| US-20100057183-A1 | MEDICAL APPLIANCE OPTICAL DELIVERY AND DEPLOYMENT APPARATUS AND METHOD | MERIT MEDICAL SYSTEMS, INC. | 2010-03-04 | — | — | US | claimed |
| US-7637934-B2 | Medical appliance optical delivery and deployment apparatus and method | MERIT MEDICAL SYSTEMS, INC. (US) | 2009-12-29 | — | — | US | claimed |
| US-7547321-B2 | Removable stent and method of using the same | ALVEOLUS INC. (US) | 2009-06-16 | — | — | US | claimed |
| EP-1424960-A4 | REMOVABLE STENT AND METHOD OF USING THE SAME | ALVEOLUS INC (US) | 2007-06-13 | — | — | EP | claimed |
| EP-1613244-A4 | MEDICAL APPLIANCE OPTICAL DELIVERY AND DEPLOYMENT APPARATUS AND METHOD | ALVEOLUS INC (US) | 2007-04-18 | — | — | EP | claimed |
| JP-2006525074-A | — | — | 2006-11-09 | — | — | JP | claimed |
| JP-2006521885-A | — | — | 2006-09-28 | — | — | JP | claimed |
| EP-1617791-A2 | BIFURCATED MEDICAL APPLIANCE DELIVERY APPARATUS AND METHOD | Alveolus Inc. (US) | 2006-01-25 | — | — | EP | claimed |
| EP-1613244-A1 | MEDICAL APPLIANCE OPTICAL DELIVERY AND DEPLOYMENT APPARATUS AND METHOD | Alveolus, Inc. (US) | 2006-01-11 | — | — | EP | claimed |
| WO-2004098455-A2 | BIFURCATED MEDICAL APPLIANCE DELIVERY APPARATUS AND METHOD | ALVEOLUS INC (US) | 2004-11-18 | — | — | WO | claimed |
| US-20040220653-A1 | Bifurcated medical appliance delivery apparatus and method | WELLS FARGO BANK, NATIONAL ASSOCIATION, AS ADMINISTRATIVE AGENT | 2004-11-04 | — | — | US | claimed |
| WO-2004091452-A1 | MEDICAL APPLIANCE OPTICAL DELIVERY AND DEPLOYMENT APPARATUS AND METHOD | ALVEOLUS INC (US) | 2004-10-28 | — | — | WO | claimed |
| US-20040193243-A1 | Medical appliance optical delivery and deployment apparatus and method | WELLS FARGO BANK, NATIONAL ASSOCIATION, AS ADMINISTRATIVE AGENT | 2004-09-30 | — | — | US | claimed |
| EP-1424960-A2 | REMOVABLE STENT AND METHOD OF USING THE SAME | Alveolus, Inc. (US) | 2004-06-09 | — | — | EP | claimed |
| US-20030024534-A1 | Removable stent and method of using the same | WELLS FARGO BANK, NATIONAL ASSOCIATION, AS ADMINISTRATIVE AGENT | 2003-02-06 | — | — | US | claimed |
| WO-2003009773-A2 | REMOVABLE STENT AND METHOD OF USING THE SAME | ALVEOLUS INC. (US) | 2003-02-06 | — | — | WO | claimed |
| EP-3463205-B1 | BIODEGRADABLE SUPPORTING DEVICE | Q3 MEDICAL DEVICES LTD (IE) | 2024-07-03 | — | — | EP | disclosed |
| WO-1996032107-A1 | A PHARMACEUTICAL COMPOSITION CONTAINING BENZIMIDAZOLE FOR INHIBITING THE GROWTH OF CANCERS | THE PROCTER & GAMBLE COMPANY (US) | 1996-10-17 | — | — | WO | disclosed |