Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 4/20 | 0.39 |
| ▸ | RAB9A | P51151 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | APLNR | P35414 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.32 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | ATM | Q13315 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4071668 | 0.87 | FFAR1 (0.36) | PKMMAPTMEN1KMT2AHPGD | |
| SCHEMBL4069876 | 0.82 | ABL1 (0.40) | MAPTRAB9AMEN1KMT2AHPGD | |
| SCHEMBL4073503 | 0.80 | ADRA2A (0.42) | MEN1KMT2ASMN1; SMN2LMNAATM | |
| SCHEMBL4349038 | 0.79 | PKM (0.46) | PKMMAPTRAB9AMEN1KMT2A | |
| SCHEMBL24521529 | 0.75 | PKM (0.46) | PKMMAPTRAB9AMEN1KMT2A | |
| SCHEMBL17404562 | 0.75 | PKM (0.46) | PKMMAPTRAB9AMEN1KMT2A | |
| SCHEMBL30681168 | 0.75 | PKM (0.46) | PKMMAPTRAB9AMEN1KMT2A | |
| SCHEMBL17404506 | 0.75 | PKM (0.46) | PKMMAPTRAB9AMEN1KMT2A | |
| SCHEMBL21574041 | 0.75 | PKM (0.46) | PKMMAPTRAB9AMEN1KMT2A | |
| SCHEMBL17404587 | 0.75 | PKM (0.46) | PKMMAPTRAB9AMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2066673-A2 | TRICYCLIC COMPOUNDS AND ITS USE AS TYROSINE KINASE MODULATORS | ChemBridge Research Laboratories, Inc. (US) | 2009-06-10 | — | — | EP | disclosed |
| WO-2008021369-A2 | TRICYCLIC COMPOUNDS AND ITS USE AS TYROSINE KINASE MODULATORS | CHEMBRIDGE RESEARCH LABORATORIES, INC. (US) | 2008-02-21 | — | — | WO | disclosed |