SCHEMBL407878

SCHEMBL407878

COc1cc(C)cc(B2OC(C)(C)C(C)(C)O2)c1

nearest known ligand 0.41

Predicted protein targets (top 12)

geneUniProtsupporting neighboursconfidence
CSF1R P07333 1/20 0.41
SNCA P37840 1/20 0.40
LPL P06858 12/20 0.38
LIPG Q9Y5X9 12/20 0.38
CA1 P00915 1/20 0.38
CA2 P00918 1/20 0.38
CA9 Q16790 1/20 0.38
HIF1A Q16665 1/20 0.34
ALDH1A1 P00352 1/20 0.34
ACHE P22303 1/20 0.34
NR1I2 O75469 1/20 0.32
PTPN1 P18031 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL21313419 0.89 SNCA (0.43) CSF1RSNCALPLLIPGCA1
SCHEMBL1560148 0.89 ALDH1A1 (0.46) CSF1RSNCALPLLIPGCA1
SCHEMBL28423211 0.87 PGR (0.35) CSF1RSNCALPLLIPGCA1
SCHEMBL11910688 0.82 LPL (0.45) CSF1RLPLLIPGCA1CA2
SCHEMBL4020523 0.82 LPL (0.45) CSF1RLPLLIPGCA1CA2
SCHEMBL1164931 0.81 SNCA (0.39) CSF1RSNCALPLLIPGCA1
SCHEMBL4252418 0.81 SNCA (0.39) SNCALPLLIPGCA1CA2
SCHEMBL4242311 0.81 SNCA (0.39) CSF1RSNCALPLLIPGCA1
SCHEMBL15649176 0.81 CA1 (0.41) CSF1RSNCALPLLIPGCA1
SCHEMBL16815511 0.81 LPL (0.46) CSF1RSNCALPLLIPGCA1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 49 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20260062393-A1 Compounds CTXT PTY LTD (AU) 2026-03-05 US disclosed
US-12365655-B2 Compounds CTXT PTY LTD (AU) 2025-07-22 US disclosed
EP-4335439-A2 COMPOUNDS CTXT PTY LTD (AU) 2024-03-13 EP disclosed
EP-3810602-B1 COMPOUNDS CTXT PTY LTD (AU) 2023-11-01 EP disclosed
EP-3810602-B1 COMPOUNDS CTXT PTY LTD (AU) 2023-11-01 EP disclosed
US-11731953-B2 Methods and compounds for restoring mutant p53 function PMV PHARMACEUTICALS, INC. (US) 2023-08-22 US disclosed
CN-115448957-A Novel tetradentate platinum complexes 通用显示公司 2022-12-09 CN disclosed
CN-111732611-B Novel tetradentate platinum complexes 通用显示公司 2022-08-23 CN disclosed
US-20220153710-A1 Compounds CTXT PTY LTD (AU) 2022-05-19 US disclosed
US-20220153710-A1 Compounds CTXT PTY LTD (AU) 2022-05-19 US disclosed
WO-2012116231-A2 NOVEL TETRADENTATE PLATINUM COMPLEXES UNIVERSAL DISPLAY CORPORATION (US) 2012-08-30 WO disclosed
US-20120065154-A1 Pyrazolo Pyrimidine Derivatives and Methods of Use Thereof THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2012-03-15 US disclosed
US-20120065154-A1 Pyrazolo Pyrimidine Derivatives and Methods of Use Thereof THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2012-03-15 US disclosed
US-20110028493-A1 HETEROCYCLIC DERIVATIVE AND USE THEREOF TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2011-02-03 US disclosed
US-20090181988-A1 Pyrazolo Pyrimidine Derivatives and Methods of Use Thereof THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2009-07-16 US disclosed
US-20090181988-A1 Pyrazolo Pyrimidine Derivatives and Methods of Use Thereof THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2009-07-16 US disclosed
US-7429596-B2 1H-pyrrolo [2,3-D] pyrimidine derivatives and methods of use thereof THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2008-09-30 US disclosed
US-7429596-B2 1H-pyrrolo [2,3-D] pyrimidine derivatives and methods of use thereof THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2008-09-30 US disclosed
US-7329769-B2 Catalytic boronate ester synthesis from boron reagents and hydrocarbons BOARD OF TRUSTEES OF MICHIGAN STATE UNIVERSITY (US) 2008-02-12 US disclosed
US-7329769-B2 Catalytic boronate ester synthesis from boron reagents and hydrocarbons BOARD OF TRUSTEES OF MICHIGAN STATE UNIVERSITY (US) 2008-02-12 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20220153710-A1 Compounds SLC10A1, ABCB11, PCSK9 CSF1R 3728/4885SNCA 3051/4885LPL 2655/4885
US-11731953-B2 Methods and compounds for restoring mutant p53 function TP53, TP53BP1, HRAS CSF1R 3924/4885SNCA 4236/4885LPL 3322/4885
US-20260062393-A1 Compounds SCN2B, ABCB11, SCN1B CSF1R 1769/4885SNCA 1718/4885LPL 2197/4885
US-20090181988-A1 Pyrazolo Pyrimidine Derivatives and Methods of Use Thereof DPYD, DHODH, DLD CSF1R 2386/4885SNCA 3533/4885LPL 1784/4885
US-20110028493-A1 HETEROCYCLIC DERIVATIVE AND USE THEREOF PDE3B, PDE5A, PDE2A CSF1R 3312/4885SNCA 1368/4885LPL 2103/4885
US-20120065154-A1 Pyrazolo Pyrimidine Derivatives and Methods of Use Thereof DPYD, DHODH, DLD CSF1R 2386/4885SNCA 3533/4885LPL 1784/4885
US-12365655-B2 Compounds SLC10A1, ABCB11, PCSK9 CSF1R 3730/4885SNCA 3052/4885LPL 2661/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.