Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN9A | Q15858 | 3/20 | 0.43 |
| ▸ | HSD11B1 | P28845 | 6/20 | 0.36 |
| ▸ | HSD11B2 | P80365 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | ADAMTS5 | Q9UNA0 | 2/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.32 |
| ▸ | MMP2 | P08253 | 1/20 | 0.31 |
| ▸ | MMP14 | P50281 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4084557 | 0.92 | SCN9A (0.39) | SCN9AHSD11B1HSD11B2ALDH1A1 | |
| SCHEMBL75799 | 0.89 | HSD11B1 (0.40) | HSD11B1HSD11B2 | |
| SCHEMBL75902 | 0.87 | HSD11B1 (0.39) | SCN9AHSD11B1HSD11B2MAPK1NPSR1 | |
| SCHEMBL75991 | 0.85 | HSD11B1 (0.41) | HSD11B1 | |
| SCHEMBL4079305 | 0.84 | TOP2A (0.39) | SCN9AHSD11B1HSD11B2ALDH1A1 | |
| SCHEMBL4081955 | 0.84 | DGAT1 (0.37) | SCN9AHSD11B1HSD11B2 | |
| SCHEMBL4089235 | 0.82 | SCN9A (0.39) | SCN9AHSD11B1 | |
| SCHEMBL4083851 | 0.81 | SCN9A (0.39) | SCN9AHSD11B1HSD11B2 | |
| SCHEMBL4083612 | 0.81 | SCN9A (0.39) | SCN9AHSD11B1HSD11B2ALDH1A1NPSR1 | |
| SCHEMBL72961 | 0.81 | HSD11B1 (0.43) | HSD11B1HSD11B2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2104665-A2 | IMIDAZOLONE AND IMIDAZOLIDINONE DERIVATIVES AS 11B-HSD1 INHIBITORS FOR DIABETES | F. Hoffmann-Roche AG (CH) | 2009-09-30 | — | — | EP | disclosed |
| WO-2008046758-A2 | IMIDAZOLONE AND IMIDAZOLIDINONE DERIVATIVES AS 11B-HSD1 INHIBITORS FOR DIABETES | F. HOFFMANN-LA ROCHE AG (CH) | 2008-04-24 | — | — | WO | disclosed |