Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TOP2A | P11388 | 1/20 | 0.39 |
| ▸ | P2RX5 | Q93086 | 1/20 | 0.38 |
| ▸ | P2RX4 | Q99571 | 1/20 | 0.38 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.38 |
| ▸ | P2RX2 | Q9UBL9 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 3/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.37 |
| ▸ | PKM | P14618 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | CNR2 | P34972 | 1/20 | 0.37 |
| ▸ | PDE4A | P27815 | 2/20 | 0.37 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.37 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.37 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.37 |
| ▸ | CTSD | P07339 | 1/20 | 0.37 |
| ▸ | BACE1 | P56817 | 1/20 | 0.37 |
| ▸ | BACE2 | Q9Y5Z0 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4084557 | 0.87 | SCN9A (0.39) | ALDH1A1SCN9AHSD11B1HSD11B2 | |
| SCHEMBL4081955 | 0.86 | DGAT1 (0.37) | KMT2ASCN9AHSD11B1HSD11B2 | |
| SCHEMBL4079039 | 0.84 | SCN9A (0.43) | ALDH1A1SCN9AHSD11B1HSD11B2 | |
| SCHEMBL75902 | 0.84 | HSD11B1 (0.39) | P2RX7SCN9AHSD11B1HSD11B2 | |
| SCHEMBL4089235 | 0.79 | SCN9A (0.39) | KMT2ACNR2BACE1BACE2SCN9A | |
| SCHEMBL4083612 | 0.78 | SCN9A (0.39) | P2RX7ALDH1A1CNR2SCN9AHSD11B1 | |
| SCHEMBL4083851 | 0.78 | SCN9A (0.39) | P2RX7CNR2SCN9AHSD11B1HSD11B2 | |
| SCHEMBL72961 | 0.77 | HSD11B1 (0.43) | HSD11B1HSD11B2 | |
| SCHEMBL75657 | 0.77 | HSD11B1 (0.43) | HSD11B1HSD11B2 | |
| SCHEMBL72960 | 0.77 | HSD11B1 (0.43) | HSD11B1HSD11B2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2104665-A2 | IMIDAZOLONE AND IMIDAZOLIDINONE DERIVATIVES AS 11B-HSD1 INHIBITORS FOR DIABETES | F. Hoffmann-Roche AG (CH) | 2009-09-30 | — | — | EP | disclosed |
| WO-2008046758-A2 | IMIDAZOLONE AND IMIDAZOLIDINONE DERIVATIVES AS 11B-HSD1 INHIBITORS FOR DIABETES | F. HOFFMANN-LA ROCHE AG (CH) | 2008-04-24 | — | — | WO | disclosed |