Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TUBB4A | P04350 | 1/20 | 0.52 |
| ▸ | TUBB | P07437 | 1/20 | 0.52 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.52 |
| ▸ | TUBA1B | P68363 | 1/20 | 0.52 |
| ▸ | TUBA4A | P68366 | 1/20 | 0.52 |
| ▸ | TUBB4B | P68371 | 1/20 | 0.52 |
| ▸ | TUBB3 | Q13509 | 1/20 | 0.52 |
| ▸ | TUBB2A | Q13885 | 1/20 | 0.52 |
| ▸ | TUBB8 | Q3ZCM7 | 1/20 | 0.52 |
| ▸ | TUBA3E | Q6PEY2 | 1/20 | 0.52 |
| ▸ | TUBA1A | Q71U36 | 1/20 | 0.52 |
| ▸ | TUBA1C | Q9BQE3 | 1/20 | 0.52 |
| ▸ | TUBB6 | Q9BUF5 | 1/20 | 0.52 |
| ▸ | TUBB2B | Q9BVA1 | 1/20 | 0.52 |
| ▸ | TUBB1 | Q9H4B7 | 1/20 | 0.52 |
| ▸ | HPGD | P15428 | 2/20 | 0.49 |
| ▸ | NPC1 | O15118 | 2/20 | 0.49 |
| ▸ | RAB9A | P51151 | 2/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4085165 | 1.00 | TUBB4A (0.52) | TUBB4ATUBBTUBA3CTUBA1BTUBA4A | |
| SCHEMBL4080197 | 0.86 | TUBB4A (0.54) | TUBB4ATUBBTUBA3CTUBA1BTUBA4A | |
| SCHEMBL2685097 | 0.84 | GUSB (0.70) | TUBB4ATUBBTUBA3CTUBA1BTUBA4A | |
| SCHEMBL1461157 | 0.83 | GUSB (0.68) | HPGDNPC1RAB9AALDH1A1HTT | |
| SCHEMBL29784109 | 0.83 | GUSB (0.68) | HPGDNPC1RAB9AALDH1A1HTT | |
| SCHEMBL11381348 | 0.82 | EGLN1 (0.54) | HPGDNPC1RAB9AALDH1A1HTT | |
| Ammonia Solution, Strong SCHEMBL2685964 | 0.79 | GUSB (0.49) | TUBB4ATUBBTUBA3CTUBA1BTUBA4A | |
| SCHEMBL4188092 | 0.77 | GUSB (0.47) | TUBB4ATUBBTUBA3CTUBA1BTUBA4A | |
| SCHEMBL6014177 | 0.76 | TYMS (0.72) | TUBB4ATUBBTUBA3CTUBA1BTUBA4A | |
| Ammonia Solution, Strong SCHEMBL2685962 | 0.76 | GUSB (0.46) | TUBB4ATUBBTUBA3CTUBA1BTUBA4A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20160158390-A1 | Methods for Tumor Diagnosis and Therapy | PRESIDENT AND FELLOWS OF HARVARD COLLEGE | 2016-06-09 | — | — | US | disclosed |
| US-9186425-B2 | Methods for tumor diagnosis and therapy | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2015-11-17 | — | — | US | disclosed |
| US-20140178298-A1 | METHODS FOR TUMOR DIAGNOSIS AND THERAPY | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2014-06-26 | — | — | US | disclosed |
| US-20120213701-A1 | METHODS FOR TUMOR DIAGNOSIS AND THERAPY | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2012-08-23 | — | — | US | disclosed |
| US-8168159-B2 | Compounds for tumor diagnosis and therapy | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2012-05-01 | — | — | US | disclosed |
| US-20090285755-A1 | METHODS FOR TUMOR DIAGNOSIS AND THERAPY | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2009-11-19 | — | — | US | disclosed |
| US-7514067-B2 | Complexing enzyme with antibody; trapping within tumor | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2009-04-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120213701-A1 | METHODS FOR TUMOR DIAGNOSIS AND THERAPY | FOLH1, DNPEP, ENPEP | TUBB4A 1957/4885TUBB 1956/4885TUBA3C 2741/4885 |
| US-20090285755-A1 | METHODS FOR TUMOR DIAGNOSIS AND THERAPY | FOLH1, DNPEP, ENPEP | TUBB4A 1957/4885TUBB 1956/4885TUBA3C 2741/4885 |
| US-20140178298-A1 | METHODS FOR TUMOR DIAGNOSIS AND THERAPY | FOLH1, DNPEP, ENPEP | TUBB4A 1957/4885TUBB 1956/4885TUBA3C 2741/4885 |
| US-20160158390-A1 | Methods for Tumor Diagnosis and Therapy | FOLH1, DNPEP, ENPEP | TUBB4A 1957/4885TUBB 1956/4885TUBA3C 2741/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.