Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GUSB | P08236 | 8/20 | 0.70 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.70 |
| ▸ | HPGD | P15428 | 3/20 | 0.70 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.52 |
| ▸ | TUBB | P07437 | 1/20 | 0.52 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.52 |
| ▸ | TUBA1B | P68363 | 1/20 | 0.52 |
| ▸ | TUBA4A | P68366 | 1/20 | 0.52 |
| ▸ | TUBB4B | P68371 | 1/20 | 0.52 |
| ▸ | TUBB3 | Q13509 | 1/20 | 0.52 |
| ▸ | TUBB2A | Q13885 | 1/20 | 0.52 |
| ▸ | TUBB8 | Q3ZCM7 | 1/20 | 0.52 |
| ▸ | TUBA3E | Q6PEY2 | 1/20 | 0.52 |
| ▸ | TUBA1A | Q71U36 | 1/20 | 0.52 |
| ▸ | TUBA1C | Q9BQE3 | 1/20 | 0.52 |
| ▸ | TUBB6 | Q9BUF5 | 1/20 | 0.52 |
| ▸ | TUBB2B | Q9BVA1 | 1/20 | 0.52 |
| ▸ | TUBB1 | Q9H4B7 | 1/20 | 0.52 |
| ▸ | PDE5A | O76074 | 2/20 | 0.51 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4090569 | 0.84 | GUSB (0.70) | GUSBKDM4EHPGDTUBB4ATUBB | |
| SCHEMBL4080440 | 0.84 | TUBB4A (0.52) | GUSBKDM4EHPGDTUBB4ATUBB | |
| SCHEMBL11243512 | 0.84 | GUSB (0.70) | GUSBKDM4EHPGDTUBB4ATUBB | |
| SCHEMBL12591987 | 0.84 | GUSB (0.70) | GUSBKDM4EHPGDPDE5AHSD17B10 | |
| SCHEMBL4085165 | 0.84 | TUBB4A (0.52) | GUSBKDM4EHPGDTUBB4ATUBB | |
| SCHEMBL30259689 | 0.83 | GUSB (1.00) | GUSBKDM4EHPGDPDE5AHSD17B10 | |
| SCHEMBL29890314 | 0.83 | GUSB (1.00) | GUSBKDM4EHPGDPDE5AHSD17B10 | |
| SCHEMBL296097 | 0.83 | GUSB (1.00) | GUSBKDM4EHPGDPDE5AHSD17B10 | |
| SCHEMBL12591993 | 0.82 | GUSB (0.67) | GUSBKDM4EHPGDPDE5AHSD17B10 | |
| SCHEMBL12591989 | 0.81 | GUSB (0.65) | GUSBKDM4EHPGDPDE5AHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 23 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20160158390-A1 | Methods for Tumor Diagnosis and Therapy | PRESIDENT AND FELLOWS OF HARVARD COLLEGE | 2016-06-09 | — | — | US | disclosed |
| US-20160158390-A1 | Methods for Tumor Diagnosis and Therapy | PRESIDENT AND FELLOWS OF HARVARD COLLEGE | 2016-06-09 | — | — | US | disclosed |
| US-20160158390-A1 | Methods for Tumor Diagnosis and Therapy | PRESIDENT AND FELLOWS OF HARVARD COLLEGE | 2016-06-09 | — | — | US | disclosed |
| US-9186425-B2 | Methods for tumor diagnosis and therapy | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2015-11-17 | — | — | US | disclosed |
| US-9186425-B2 | Methods for tumor diagnosis and therapy | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2015-11-17 | — | — | US | disclosed |
| US-9186425-B2 | Methods for tumor diagnosis and therapy | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2015-11-17 | — | — | US | disclosed |
| US-20140178298-A1 | METHODS FOR TUMOR DIAGNOSIS AND THERAPY | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2014-06-26 | — | — | US | disclosed |
| US-20140178298-A1 | METHODS FOR TUMOR DIAGNOSIS AND THERAPY | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2014-06-26 | — | — | US | disclosed |
| US-20140178298-A1 | METHODS FOR TUMOR DIAGNOSIS AND THERAPY | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2014-06-26 | — | — | US | disclosed |
| US-8603437-B2 | Methods for tumor diagnosis and therapy | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2013-12-10 | — | — | US | disclosed |
| US-8168159-B2 | Compounds for tumor diagnosis and therapy | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2012-05-01 | — | — | US | disclosed |
| US-8168159-B2 | Compounds for tumor diagnosis and therapy | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2012-05-01 | — | — | US | disclosed |
| US-8168159-B2 | Compounds for tumor diagnosis and therapy | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2012-05-01 | — | — | US | disclosed |
| US-20090285755-A1 | METHODS FOR TUMOR DIAGNOSIS AND THERAPY | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2009-11-19 | — | — | US | disclosed |
| US-20090285755-A1 | METHODS FOR TUMOR DIAGNOSIS AND THERAPY | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2009-11-19 | — | — | US | disclosed |
| US-20090285755-A1 | METHODS FOR TUMOR DIAGNOSIS AND THERAPY | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2009-11-19 | — | — | US | disclosed |
| US-7514067-B2 | Complexing enzyme with antibody; trapping within tumor | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2009-04-07 | — | — | US | disclosed |
| US-7514067-B2 | Complexing enzyme with antibody; trapping within tumor | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2009-04-07 | — | — | US | disclosed |
| US-7514067-B2 | Complexing enzyme with antibody; trapping within tumor | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2009-04-07 | — | — | US | disclosed |
| US-20030021791-A1 | Complexing enzyme with antibody; trapping within tumor | PRESIDENT AND FELLOWS OF HARVARD COLLEGE | 2003-01-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090285755-A1 | METHODS FOR TUMOR DIAGNOSIS AND THERAPY | FOLH1, DNPEP, ENPEP | GUSB 21/4885KDM4E 4072/4885HPGD 595/4885 |
| US-20030021791-A1 | Complexing enzyme with antibody; trapping within tumor | RNASE1, TMPRSS15, FCGR3B | GUSB 41/4885KDM4E 3590/4885HPGD 1954/4885 |
| US-20140178298-A1 | METHODS FOR TUMOR DIAGNOSIS AND THERAPY | FOLH1, DNPEP, ENPEP | GUSB 21/4885KDM4E 4072/4885HPGD 595/4885 |
| US-20160158390-A1 | Methods for Tumor Diagnosis and Therapy | FOLH1, DNPEP, ENPEP | GUSB 21/4885KDM4E 4072/4885HPGD 595/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.