Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRSS1 | P07477 | 8/20 | 0.49 |
| ▸ | HDAC3 | O15379 | 5/20 | 0.48 |
| ▸ | HDAC1 | Q13547 | 5/20 | 0.48 |
| ▸ | HDAC2 | Q92769 | 4/20 | 0.48 |
| ▸ | F2 | P00734 | 2/20 | 0.47 |
| ▸ | PRSS2 | P07478 | 2/20 | 0.47 |
| ▸ | PRSS3 | P35030 | 2/20 | 0.47 |
| ▸ | TMPRSS6 | Q8IU80 | 2/20 | 0.47 |
| ▸ | ST14 | Q9Y5Y6 | 2/20 | 0.47 |
| ▸ | MPO | P05164 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | KDM5A | P29375 | 1/20 | 0.46 |
| ▸ | BLM | P54132 | 1/20 | 0.46 |
| ▸ | GFER | P55789 | 1/20 | 0.46 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.46 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.46 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.46 |
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.45 |
| ▸ | OGG1 | O15527 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4079962 | 0.98 | PRSS1 (0.50) | PRSS1HDAC3HDAC1HDAC2F2 | |
| SCHEMBL4072414 | 0.95 | MPO (0.47) | PRSS1HDAC3HDAC1HDAC2F2 | |
| SCHEMBL4071505 | 0.88 | MPO (0.50) | PRSS1MPOCYP3A4KDM5ABLM | |
| SCHEMBL11071683 | 0.81 | PLK1 (0.56) | PRSS1HDAC3HDAC1HDAC2F2 | |
| SCHEMBL10764251 | 0.80 | SCN5A (0.56) | PRSS1HDAC3HDAC1HDAC2MPO | |
| SCHEMBL960116 | 0.80 | CYP3A4 (0.52) | HDAC3HDAC1HDAC2MPOCYP3A4 | |
| SCHEMBL10457154 | 0.78 | L3MBTL1 (0.61) | HDAC3HDAC1HDAC2CYP3A4NCOR2 | |
| SCHEMBL4079637 | 0.76 | L3MBTL1 (0.68) | MPOCYP3A4KDM5ABLMGFER | |
| SCHEMBL2833538 | 0.73 | CA1 (0.62) | ALDH1A1 | |
| SCHEMBL4079501 | 0.73 | HCAR3 (0.52) | HDAC1MPOCYP3A4KDM5ABLM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009155362-A1 | SMALL MOLECULE HEMATOPOIETIC GROWTH FACTOR MIMETIC COMPOUNDS AND THEIR USES | LIGAND PHARMACEUTICALS INC. (US) | 2009-12-23 | — | — | WO | disclosed |