Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 8/20 | 0.42 |
| ▸ | NPC1 | O15118 | 7/20 | 0.42 |
| ▸ | PKM | P14618 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.42 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.42 |
| ▸ | NFKB2 | Q00653 | 2/20 | 0.42 |
| ▸ | RELA | Q04206 | 2/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.41 |
| ▸ | MEN1 | O00255 | 3/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | PRKCB | P05771 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 2/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | KDM5A | P29375 | 1/20 | 0.35 |
| ▸ | GSK3B | P49841 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2905204 | 0.91 | NPC1 (0.41) | RAB9ANPC1PKMSMN1; SMN2NFKB1 | |
| SCHEMBL4083886 | 0.84 | AURKA (0.44) | RAB9ANPC1PKMSMN1; SMN2NFKB1 | |
| SCHEMBL4092000 | 0.80 | HPGD (0.43) | RAB9ANPC1PKMSMN1; SMN2NFKB1 | |
| SCHEMBL4088627 | 0.80 | PRKCB (0.36) | ROCK1PRKCBGSK3BDYRK1A | |
| SCHEMBL650566 | 0.80 | AURKA (0.40) | RAB9ANPC1PKMSMN1; SMN2NFKB1 | |
| SCHEMBL4088628 | 0.79 | RAB9A (0.43) | RAB9ANPC1PKMSMN1; SMN2HPGD | |
| SCHEMBL4088564 | 0.78 | MAPT (0.48) | RAB9ANPC1PKMSMN1; SMN2NFKB1 | |
| SCHEMBL4078387 | 0.78 | MAPK1 (0.48) | RAB9ANPC1PKMSMN1; SMN2LMNA | |
| SCHEMBL4081353 | 0.78 | BRAF (0.39) | SMN1; SMN2LMNAL3MBTL1ALDH1A1PRKCB | |
| SCHEMBL4083540 | 0.77 | FGFR1 (0.50) | RAB9ANPC1KMT2AMEN1ROCK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2058315-A1 | 1H-Furo[3,2-C]Pyrazoles active as aurora kinase inhibitors | Nerviano Medical Sciences S.r.l. (IT) | 2009-05-13 | — | — | EP | disclosed |