Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKA | O14965 | 1/20 | 0.44 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.42 |
| ▸ | ABL1 | P00519 | 2/20 | 0.40 |
| ▸ | BCR | P11274 | 2/20 | 0.40 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 7/20 | 0.38 |
| ▸ | RAB9A | P51151 | 7/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.36 |
| ▸ | NFKB2 | Q00653 | 2/20 | 0.36 |
| ▸ | RELA | Q04206 | 2/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.35 |
| ▸ | USP36 | Q9P275 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL650566 | 0.94 | AURKA (0.40) | AURKAEGLN1ABL1BCRROCK1 | |
| SCHEMBL4086360 | 0.85 | MAPK1 (0.47) | AURKAEGLN1ABL1BCRNPC1 | |
| SCHEMBL4092674 | 0.85 | AURKA (0.43) | AURKAEGLN1ABL1BCRMAPK1 | |
| SCHEMBL4088217 | 0.85 | AURKA (0.51) | AURKAABL1BCRROCK1MAPK1 | |
| SCHEMBL4081173 | 0.84 | RAB9A (0.42) | ROCK1NPC1RAB9APKMSMN1; SMN2 | |
| SCHEMBL4078547 | 0.84 | AURKA (0.46) | AURKAEGLN1ABL1BCRNPC1 | |
| SCHEMBL4093027 | 0.83 | RAB9A (0.44) | AURKANPC1RAB9ASMN1; SMN2TP53 | |
| SCHEMBL4083114 | 0.83 | AURKA (0.41) | AURKAABL1BCRNPC1RAB9A | |
| SCHEMBL4078238 | 0.83 | AURKA (0.43) | AURKAEGLN1ABL1BCRSMN1; SMN2 | |
| SCHEMBL4089328 | 0.83 | AURKA (0.43) | AURKAEGLN1ABL1BCRROCK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2058315-A1 | 1H-Furo[3,2-C]Pyrazoles active as aurora kinase inhibitors | Nerviano Medical Sciences S.r.l. (IT) | 2009-05-13 | — | — | EP | disclosed |