Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 3/20 | 0.39 |
| ▸ | TAS2R8 | Q9NYW2 | 1/20 | 0.38 |
| ▸ | PRKCB | P05771 | 2/20 | 0.38 |
| ▸ | CCNE1 | P24864 | 2/20 | 0.37 |
| ▸ | CDK2 | P24941 | 2/20 | 0.37 |
| ▸ | GSK3B | P49841 | 1/20 | 0.37 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.37 |
| ▸ | KDR | P35968 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.35 |
| ▸ | GAA | P10253 | 2/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | BACE1 | P56817 | 1/20 | 0.34 |
| ▸ | RAF1 | P04049 | 2/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4078238 | 0.84 | AURKA (0.43) | BRAFTAS2R8PRKCBFGFR1KDR | |
| SCHEMBL4088628 | 0.83 | RAB9A (0.43) | CCNE1CDK2GSK3BALDH1A1GAA | |
| SCHEMBL4092000 | 0.82 | HPGD (0.43) | TAS2R8ALDH1A1SMN1; SMN2POLBLMNA | |
| SCHEMBL4088278 | 0.81 | KDM4E (0.41) | ALDH1A1POLBLMNAL3MBTL1 | |
| SCHEMBL4081173 | 0.78 | RAB9A (0.42) | PRKCBGSK3BALDH1A1SMN1; SMN2POLB | |
| SCHEMBL4088627 | 0.78 | PRKCB (0.36) | PRKCBGSK3BFGFR1KDRBACE1 | |
| SCHEMBL4087457 | 0.77 | KLK7 (0.47) | ALDH1A1GAASMN1; SMN2POLBLMNA | |
| SCHEMBL4088557 | 0.77 | SMN1; SMN2 (0.48) | ALDH1A1SMN1; SMN2POLBL3MBTL1 | |
| SCHEMBL4081816 | 0.76 | MAPT (0.47) | ALDH1A1SMN1; SMN2POLBLMNA | |
| SCHEMBL4078618 | 0.76 | CDK7 (0.35) | CDK2GSK3BGAASMN1; SMN2POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2058315-A1 | 1H-Furo[3,2-C]Pyrazoles active as aurora kinase inhibitors | Nerviano Medical Sciences S.r.l. (IT) | 2009-05-13 | — | — | EP | claimed |
| EP-2058315-A1 | 1H-Furo[3,2-C]Pyrazoles active as aurora kinase inhibitors | Nerviano Medical Sciences S.r.l. (IT) | 2009-05-13 | — | — | EP | disclosed |