Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PKM | P14618 | 8/20 | 0.65 |
| ▸ | TAS2R46 | P59540 | 4/20 | 0.65 |
| ▸ | MEN1 | O00255 | 2/20 | 0.65 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.65 |
| ▸ | RECQL | P46063 | 1/20 | 0.65 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.65 |
| ▸ | TERT | O14746 | 1/20 | 0.65 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.40 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.36 |
| ▸ | LMNA | P02545 | 3/20 | 0.36 |
| ▸ | TP53 | P04637 | 3/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.36 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.36 |
| ▸ | STAT6 | P42226 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | CASP1 | P29466 | 1/20 | 0.36 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.36 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13629609 | 1.00 | PKM (0.65) | PKMTAS2R46MEN1KMT2ARECQL | |
| SCHEMBL4081707 | 1.00 | PKM (0.65) | PKMTAS2R46MEN1KMT2ARECQL | |
| SCHEMBL4090929 | 0.90 | PKM (0.64) | PKMTAS2R46MEN1KMT2ARECQL | |
| SCHEMBL13629610 | 0.90 | PKM (0.64) | PKMTAS2R46MEN1KMT2ARECQL | |
| SCHEMBL4090925 | 0.90 | PKM (0.64) | PKMTAS2R46MEN1KMT2ARECQL | |
| SCHEMBL31487118 | 0.82 | PKM (0.74) | PKMTAS2R46MEN1KMT2ARECQL | |
| SCHEMBL4097327 | 0.80 | PKM (0.61) | PKMTAS2R46MEN1KMT2ARECQL | |
| SCHEMBL13629605 | 0.80 | PKM (0.61) | PKMTAS2R46MEN1KMT2ARECQL | |
| SCHEMBL4097330 | 0.80 | PKM (0.61) | PKMTAS2R46MEN1KMT2ARECQL | |
| SCHEMBL4755810 | 0.80 | PKM (0.61) | PKMTAS2R46MEN1KMT2ARECQL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7622465-B2 | Costunolide derivatives | HUTCHISON MEDIPHARMA ENTERPRISES LIMITED (BS) | 2009-11-24 | — | — | US | disclosed |
| US-20090131427-A1 | Costunolide Derivatives | HUTCHISON MEDIPHARMA ENTERPRISES LIMITED (BS) | 2009-05-21 | — | — | US | disclosed |
| US-7488836-B2 | Costunolide derivatives | HUTCHISON MEDIPHARMA ENTERPRISES LIMITED (BS) | 2009-02-10 | — | — | US | disclosed |
| US-20080051396-A1 | COSTUNOLIDE DERIVATIVES | HUTCHISON MEDIPHARMA LIMITED (BS) | 2008-02-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090131427-A1 | Costunolide Derivatives | NOS1, NFKBIA, NOS2 | PKM 4351/4885TAS2R46 2774/4885MEN1 1603/4885 |
| US-20080051396-A1 | COSTUNOLIDE DERIVATIVES | NOS1, NFKBIA, RELA | PKM 3601/4885TAS2R46 3240/4885MEN1 1427/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.