Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKA | O14965 | 1/20 | 0.43 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.40 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.40 |
| ▸ | NAMPT | P43490 | 1/20 | 0.38 |
| ▸ | EGLN1 | Q9GZT9 | 3/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | POLB | P06746 | 2/20 | 0.37 |
| ▸ | KDR | P35968 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.36 |
| ▸ | PRKCB | P05771 | 1/20 | 0.36 |
| ▸ | GRM1 | Q13255 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | ABL1 | P00519 | 2/20 | 0.35 |
| ▸ | BCR | P11274 | 2/20 | 0.35 |
| ▸ | CNR1 | P21554 | 3/20 | 0.35 |
| ▸ | CNR2 | P34972 | 3/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL651138 | 0.94 | AURKA (0.40) | AURKAROCK2ROCK1NAMPTEGLN1 | |
| SCHEMBL4078547 | 0.85 | AURKA (0.46) | AURKAEGLN1KDM4EPOLBMAPK1 | |
| SCHEMBL4086360 | 0.84 | MAPK1 (0.47) | AURKAEGLN1KDRMAPK1RAB9A | |
| SCHEMBL4088217 | 0.84 | AURKA (0.51) | AURKAROCK2ROCK1MAPK1ABL1 | |
| SCHEMBL4082256 | 0.84 | AURKA (0.44) | AURKANAMPTEGLN1MAPK1TSHR | |
| SCHEMBL4083886 | 0.83 | AURKA (0.44) | AURKAROCK1EGLN1MAPK1RAB9A | |
| SCHEMBL4092674 | 0.82 | AURKA (0.43) | AURKAEGLN1MAPK1ABL1BCR | |
| SCHEMBL2913924 | 0.82 | KDR (0.36) | AURKAROCK2ROCK1NAMPTEGLN1 | |
| SCHEMBL2911561 | 0.81 | ROCK2 (0.40) | ROCK2ROCK1NAMPTKDM4EPOLB | |
| SCHEMBL4093027 | 0.81 | RAB9A (0.44) | AURKAKDM4EMAPTRAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2058315-A1 | 1H-Furo[3,2-C]Pyrazoles active as aurora kinase inhibitors | Nerviano Medical Sciences S.r.l. (IT) | 2009-05-13 | — | — | EP | disclosed |