Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 4/20 | 0.47 |
| ▸ | AURKA | O14965 | 1/20 | 0.42 |
| ▸ | EGLN1 | Q9GZT9 | 3/20 | 0.40 |
| ▸ | CA1 | P00915 | 1/20 | 0.39 |
| ▸ | CA2 | P00918 | 1/20 | 0.39 |
| ▸ | ANO1 | Q5XXA6 | 1/20 | 0.39 |
| ▸ | ABL1 | P00519 | 1/20 | 0.37 |
| ▸ | BCR | P11274 | 1/20 | 0.37 |
| ▸ | USP36 | Q9P275 | 1/20 | 0.36 |
| ▸ | FLT3 | P36888 | 1/20 | 0.36 |
| ▸ | KCNK3 | O14649 | 1/20 | 0.36 |
| ▸ | KCNK9 | Q9NPC2 | 1/20 | 0.36 |
| ▸ | KDR | P35968 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 3/20 | 0.36 |
| ▸ | RAB9A | P51151 | 3/20 | 0.36 |
| ▸ | PKM | P14618 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4083789 | 0.90 | EGLN1 (0.42) | MAPK1AURKAEGLN1ANO1ABL1 | |
| SCHEMBL4083114 | 0.89 | AURKA (0.41) | MAPK1AURKAANO1ABL1BCR | |
| SCHEMBL4088217 | 0.88 | AURKA (0.51) | MAPK1AURKAABL1BCRUSP36 | |
| SCHEMBL4093027 | 0.87 | RAB9A (0.44) | AURKANPC1RAB9ASMN1; SMN2 | |
| SCHEMBL4092674 | 0.86 | AURKA (0.43) | MAPK1AURKAEGLN1ANO1ABL1 | |
| SCHEMBL4092679 | 0.85 | AURKA (0.49) | MAPK1AURKAABL1BCRUSP36 | |
| SCHEMBL4083886 | 0.85 | AURKA (0.44) | MAPK1AURKAEGLN1ABL1BCR | |
| SCHEMBL4088455 | 0.85 | AURKA (0.47) | MAPK1AURKAEGLN1ABL1BCR | |
| SCHEMBL4078785 | 0.84 | AURKA (0.42) | MAPK1AURKAABL1BCRNPC1 | |
| SCHEMBL4088406 | 0.84 | ALDH1A1 (0.47) | MAPK1AURKAEGLN1ABL1BCR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2058315-A1 | 1H-Furo[3,2-C]Pyrazoles active as aurora kinase inhibitors | Nerviano Medical Sciences S.r.l. (IT) | 2009-05-13 | — | — | EP | disclosed |