Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKA | O14965 | 1/20 | 0.43 |
| ▸ | PHGDH | O43175 | 1/20 | 0.35 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.35 |
| ▸ | ABL1 | P00519 | 2/20 | 0.34 |
| ▸ | BCR | P11274 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | USP2 | O75604 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.34 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | IMPDH2 | P12268 | 1/20 | 0.32 |
| ▸ | USP36 | Q9P275 | 1/20 | 0.32 |
| ▸ | AADAT | Q8N5Z0 | 1/20 | 0.32 |
| ▸ | CNR1 | P21554 | 2/20 | 0.32 |
| ▸ | CNR2 | P34972 | 2/20 | 0.32 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.32 |
| ▸ | TACR3 | P29371 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4078238 | 0.85 | AURKA (0.43) | AURKAPHGDHABL1BCRMAPK1 | |
| SCHEMBL4088278 | 0.84 | KDM4E (0.41) | AURKAKDM4EUSP2MAPTRIPK1 | |
| SCHEMBL4082057 | 0.84 | KMT2A (0.44) | AURKAUSP2 | |
| SCHEMBL4088217 | 0.83 | AURKA (0.51) | AURKAABL1BCRMAPK1IMPDH2 | |
| SCHEMBL4082256 | 0.83 | AURKA (0.44) | AURKAPHGDHABL1BCRMAPK1 | |
| SCHEMBL4083886 | 0.82 | AURKA (0.44) | AURKAPHGDHABL1BCRMAPK1 | |
| SCHEMBL4078785 | 0.82 | AURKA (0.42) | AURKAABL1BCRKDM4EMAPK1 | |
| SCHEMBL4088406 | 0.82 | ALDH1A1 (0.47) | AURKAABL1BCRKDM4EMAPK1 | |
| SCHEMBL4078547 | 0.81 | AURKA (0.46) | AURKAPHGDHABL1BCRKDM4E | |
| SCHEMBL4093027 | 0.80 | RAB9A (0.44) | AURKAKDM4EUSP2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2058315-A1 | 1H-Furo[3,2-C]Pyrazoles active as aurora kinase inhibitors | Nerviano Medical Sciences S.r.l. (IT) | 2009-05-13 | — | — | EP | disclosed |