Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HIF1A | Q16665 | 6/20 | 0.54 |
| ▸ | EPAS1 | Q99814 | 6/20 | 0.54 |
| ▸ | NPC1 | O15118 | 5/20 | 0.51 |
| ▸ | RAB9A | P51151 | 4/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.51 |
| ▸ | AURKA | O14965 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 3/20 | 0.49 |
| ▸ | TP53 | P04637 | 3/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.48 |
| ▸ | USP2 | O75604 | 1/20 | 0.48 |
| ▸ | CDK2 | P24941 | 1/20 | 0.48 |
| ▸ | FLT3 | P36888 | 1/20 | 0.48 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4082914 | 0.92 | HRH3 (0.48) | HIF1AEPAS1RAB9AALDH1A1AURKA | |
| SCHEMBL4078156 | 0.92 | KDR (0.45) | HIF1AEPAS1NPC1RAB9AALDH1A1 | |
| SCHEMBL4088588 | 0.91 | HRH3 (0.49) | HIF1AEPAS1RAB9AALDH1A1AURKA | |
| SCHEMBL4088196 | 0.90 | KDR (0.54) | AURKAHDAC1FLT3 | |
| SCHEMBL4088215 | 0.87 | HTT (0.57) | HIF1AEPAS1NPC1RAB9AALDH1A1 | |
| SCHEMBL3881571 | 0.87 | AURKA (0.61) | AURKAFLT3 | |
| SCHEMBL4081465 | 0.85 | ABL1 (0.54) | HIF1AEPAS1NPC1RAB9AALDH1A1 | |
| SCHEMBL4088344 | 0.82 | RAB9A (0.46) | HIF1AEPAS1NPC1RAB9AALDH1A1 | |
| SCHEMBL4092896 | 0.81 | HDAC6 (0.51) | NPC1RAB9ATP53SMN1; SMN2CDK2 | |
| SCHEMBL4083540 | 0.80 | FGFR1 (0.50) | NPC1RAB9AAURKAMAPK1CDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2058315-A1 | 1H-Furo[3,2-C]Pyrazoles active as aurora kinase inhibitors | Nerviano Medical Sciences S.r.l. (IT) | 2009-05-13 | — | — | EP | disclosed |