Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.48 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.47 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.47 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.47 |
| ▸ | KDR | P35968 | 2/20 | 0.45 |
| ▸ | ABL1 | P00519 | 1/20 | 0.45 |
| ▸ | BCR | P11274 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | TNF | P01375 | 1/20 | 0.43 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.43 |
| ▸ | EPAS1 | Q99814 | 2/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.43 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | AURKA | O14965 | 2/20 | 0.43 |
| ▸ | KIT | P10721 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4088588 | 0.99 | HRH3 (0.49) | HRH3HDAC1HDAC8HDAC6KDR | |
| SCHEMBL4078156 | 0.98 | KDR (0.45) | HRH3HDAC1HDAC8HDAC6KDR | |
| SCHEMBL4088196 | 0.92 | KDR (0.54) | HDAC1HDAC8HDAC6KDRAURKA | |
| SCHEMBL4083450 | 0.92 | HIF1A (0.54) | HDAC1HIF1AEPAS1ALDH1A1RAB9A | |
| SCHEMBL4092903 | 0.85 | ABL1 (0.61) | HRH3HDAC1HDAC8HDAC6KDR | |
| SCHEMBL4089596 | 0.85 | FLT3 (0.49) | KDRKDM4EAURKAKITFLT3 | |
| SCHEMBL4093502 | 0.84 | ABL1 (0.63) | HRH3HDAC1KDRABL1BCR | |
| SCHEMBL4083868 | 0.83 | ABL1 (0.59) | HRH3HDAC1KDRABL1BCR | |
| SCHEMBL4092896 | 0.82 | HDAC6 (0.51) | HDAC6MAPTRAB9AFLT3CDC7 | |
| SCHEMBL4083540 | 0.81 | FGFR1 (0.50) | HDAC6KDRRAB9AAURKAFLT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2058315-A1 | 1H-Furo[3,2-C]Pyrazoles active as aurora kinase inhibitors | Nerviano Medical Sciences S.r.l. (IT) | 2009-05-13 | — | — | EP | disclosed |