Hypoxanthine

Hypoxanthine

SCHEMBL4083911

NC(=S)c1cccnc1.O=c1[nH]cnc2nc[nH]c12

nearest known ligand 0.59

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 2/20 0.49
F7 P08709 1/20 0.44
F3 P13726 1/20 0.44
SARM1 Q6SZW1 1/20 0.44
SIRT2 Q8IXJ6 1/20 0.44
SIRT6 Q8N6T7 1/20 0.44
SIRT1 Q96EB6 1/20 0.44
SIRT3 Q9NTG7 1/20 0.44
SIRT5 Q9NXA8 1/20 0.44
SIRT4 Q9Y6E7 1/20 0.44
CYP3A4 P08684 2/20 0.41
POLB P06746 1/20 0.40
CYP1A2 P05177 1/20 0.39
APP P05067 1/20 0.38
GAA P10253 1/20 0.38
HCAR3 P49019 1/20 0.38
HCAR2 Q8TDS4 1/20 0.38
GRIA1 P42261 1/20 0.38
GRIA2 P42262 1/20 0.38
GRIA3 P42263 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hypoxanthine SCHEMBL472854 0.88 F7 (0.61) ALDH1A1F7F3SARM1SIRT2
Adenine SCHEMBL622426 0.83 PI4KA (0.55) ALDH1A1F7F3SARM1SIRT2
Hypoxanthine SCHEMBL1614959 0.82 ALDH1A1 (0.50) ALDH1A1F7F3SARM1SIRT2
Adenine SCHEMBL9706219 0.81 PI4KA (0.49) ALDH1A1F7F3SARM1SIRT2
Hypoxanthine SCHEMBL9150757 0.79 SIRT2 (0.50) ALDH1A1F7F3SARM1SIRT2
Mercaptopurine Anhydrous SCHEMBL6558420 0.77 F7 (0.58) ALDH1A1F7F3SARM1SIRT2
SCHEMBL259899 0.77
SCHEMBL29480816 0.77
Bromide SCHEMBL23111928 0.75 F7 (0.61) ALDH1A1F7F3SARM1SIRT2
Hydrochloric Acid SCHEMBL27850699 0.75 F7 (0.61) ALDH1A1F7F3SARM1SIRT2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 46 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2062979-B1 Method for measuring phosphoric acid NITTO BOSEKI CO LTD (JP) 2015-11-11 EP claimed
US-8440422-B2 Method for measuring phosphoric acid NITTO BOSEKI CO., LTD. (JP) 2013-05-14 US claimed
US-20090136978-A1 METHOD FOR MEASURING PHOSPHORIC ACID NITTO BOSEKI CO., LTD. (JP) 2009-05-28 US claimed
EP-2062979-A1 Method for measuring phosphoric acid NITTO BOSEKI CO., LTD. (JP) 2009-05-27 EP claimed
US-5780256-A REACTING WITH AMINO ACID DEHYDROGENASE IN PRESENCE OF THIO-NADP OR THIO-NAD AND OTHER COENZYMES ASAHI KASEI KOGYO KABUSHIKI KAISHA (JP) 1998-07-14 US claimed
EP-0639646-B1 HIGH PRECISION DETERMINATION OF D-GLUCOSE-6-PHOSPHATE AND COMPOSITION THEREFOR ASAHI CHEMICAL IND (JP) 1998-05-06 EP claimed
EP-0632133-B1 HIGHLY SENSITIVE DETERMINATION OF D-3-HYDROXYBUTYRIC ACID OR ACETOACETIC ACID AND COMPOSITION THEREFOR ASAHI CHEMICAL IND (JP) 1998-04-22 EP claimed
US-5633143-A Method for the quantitative determination of D-3-hydroxybutyric acid and acetoacetic acid, and analytical reagent therefor ASAHI KASEI KOGYO KABUSHIKI KAISHA (JP) 1997-05-27 US claimed
EP-0727495-A2 Quantitation of inorganic phosphate and trehalose KUREHA CHEMICAL INDUSTRY CO., LTD. (JP) 1996-08-21 EP claimed
EP-0477001-B1 Highly sensitive assay method for myo-inositol and composition for practicing same ASAHI CHEMICAL IND (JP) 1996-06-26 EP claimed
EP-0437373-B1 High sensitive assay method of L-carnitine and composition for an assay ASAHI CHEMICAL IND (JP) 1996-05-29 EP claimed
EP-0639646-A1 HIGH PRECISION DETERMINATION OF D-GLUCOSE-6-PHOSPHATE AND COMPOSITION THEREFOR ASAHI KASEI KOGYO KABUSHIKI KAISHA (JP) 1995-02-22 EP claimed
EP-0632133-A1 HIGHLY SENSITIVE DETERMINATION OF D-3-HYDROXYBUTYRIC ACID OR ACETOACETIC ACID AND COMPOSITION THEREFOR Asahi Kasei Kogyo Kabushiki Kaisha (JP) 1995-01-04 EP claimed
US-5356790-A Highly sensitive assay method for myo-inositol, composition for practicing same, novel myo-inositol dehydrogenase, and process for producing same ASAHI KASEI KOGYO KABUSHIKI KAISHA (JP) 1994-10-18 US claimed
US-5266463-A Highly sensitive assay method for L-carnitine and composition for practicing same ASAHI KASEI KOGYO KABUSHIKI KAISHA (JP) 1993-11-30 US claimed
EP-0477001-A2 Highly sensitive assay method for myo-inositol and composition for practicing same ASAHI KASEI KOGYO KABUSHIKI KAISHA (JP) 1992-03-25 EP claimed
EP-0437373-A1 High sensitive assay method of L-carnitine and composition for an assay ASAHI KASEI KOGYO KABUSHIKI KAISHA (JP) 1991-07-17 EP claimed
EP-2062979-B1 Method for measuring phosphoric acid NITTO BOSEKI CO LTD (JP) 2015-11-11 EP disclosed
EP-0477001-A2 Highly sensitive assay method for myo-inositol and composition for practicing same ASAHI KASEI KOGYO KABUSHIKI KAISHA (JP) 1992-03-25 EP disclosed
EP-0437373-A1 High sensitive assay method of L-carnitine and composition for an assay ASAHI KASEI KOGYO KABUSHIKI KAISHA (JP) 1991-07-17 EP disclosed