Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIRT2 | Q8IXJ6 | 2/20 | 0.50 |
| ▸ | SIRT1 | Q96EB6 | 2/20 | 0.50 |
| ▸ | SIRT3 | Q9NTG7 | 2/20 | 0.50 |
| ▸ | F7 | P08709 | 1/20 | 0.50 |
| ▸ | F3 | P13726 | 1/20 | 0.50 |
| ▸ | SARM1 | Q6SZW1 | 1/20 | 0.50 |
| ▸ | SIRT6 | Q8N6T7 | 1/20 | 0.50 |
| ▸ | SIRT5 | Q9NXA8 | 1/20 | 0.50 |
| ▸ | SIRT4 | Q9Y6E7 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | MKNK1 | Q9BUB5 | 3/20 | 0.39 |
| ▸ | MKNK2 | Q9HBH9 | 2/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | BRD4 | O60885 | 1/20 | 0.36 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.36 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.36 |
| ▸ | PIM1 | P11309 | 2/20 | 0.36 |
| ▸ | NEK2 | P51955 | 1/20 | 0.36 |
| ▸ | APP | P05067 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hypoxanthine SCHEMBL472854 | 0.91 | F7 (0.61) | SIRT2SIRT1SIRT3F7F3 | |
| Adenine SCHEMBL755727 | 0.87 | PI4KA (0.46) | SIRT2SIRT1SIRT3F7F3 | |
| Triphosphate SCHEMBL19057041 | 0.83 | PI4KA (0.44) | SIRT2SIRT1SIRT3F7F3 | |
| Niacinamide SCHEMBL3980414 | 0.83 | F7 (0.73) | SIRT2SIRT1SIRT3F7F3 | |
| Niacinamide SCHEMBL9150765 | 0.82 | F7 (0.43) | SIRT2SIRT1SIRT3F7F3 | |
| Niacinamide SCHEMBL28907028 | 0.81 | SIRT2 (0.47) | SIRT2SIRT1SIRT3F7F3 | |
| Adenine SCHEMBL27528672 | 0.80 | PI4KA (0.50) | SIRT2SIRT1SIRT3F7F3 | |
| Adenine SCHEMBL1408059 | 0.80 | PI4KA (0.50) | SIRT2SIRT1SIRT3F7F3 | |
| Hypoxanthine SCHEMBL4083911 | 0.79 | ALDH1A1 (0.49) | SIRT2SIRT1SIRT3F7F3 | |
| Mercaptopurine Anhydrous SCHEMBL6558420 | 0.78 | F7 (0.58) | SIRT2SIRT1SIRT3F7F3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0471740-B1 | ENZYMES AND THEIR USE IN DRUG DETECTION | BRITISH TECH GROUP (GB) | 1995-08-09 | — | — | EP | disclosed |
| US-5387515-A | Oxidation in the presence of the enzyme and cofactor nadp | BRITISH TECHNOLOGY GROUP LIMITED (GB) | 1995-02-07 | — | — | US | disclosed |
| US-5298414-A | Polypeptides, oxidation for detection | BRITISH TECHNOLOGY GROUP LIMITED (GB) | 1994-03-29 | — | — | US | disclosed |