Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 6/20 | 0.57 |
| ▸ | KDM4A | O75164 | 3/20 | 0.50 |
| ▸ | KDM4C | Q9H3R0 | 3/20 | 0.50 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.49 |
| ▸ | KDM5A | P29375 | 1/20 | 0.49 |
| ▸ | PHF8 | Q9UPP1 | 1/20 | 0.49 |
| ▸ | KDM2A | Q9Y2K7 | 1/20 | 0.49 |
| ▸ | LTB4R2 | Q9NPC1 | 3/20 | 0.48 |
| ▸ | CNR2 | P34972 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | PKM | P14618 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1753870 | 0.85 | HDAC6 (0.58) | HDAC6LTB4R2CNR2LMNAPKM | |
| SCHEMBL9834381 | 0.84 | ALOX5 (0.77) | ALOX5KDM4AKDM4CHDAC6KDM5A | |
| SCHEMBL14553382 | 0.82 | ALOX5 (0.79) | ALOX5KDM4AKDM4CKDM5APHF8 | |
| SCHEMBL4077487 | 0.82 | ALOX5 (0.49) | ALOX5KDM4AKDM4CKDM5APHF8 | |
| SCHEMBL9836200 | 0.79 | ALOX5 (0.74) | ALOX5KDM4AKDM4CHDAC6KDM5A | |
| SCHEMBL14229453 | 0.79 | LTB4R2 (0.62) | HDAC6LTB4R2CNR2LMNAPKM | |
| SCHEMBL15546987 | 0.79 | CNR2 (0.64) | HDAC6LTB4R2CNR2LMNAPKM | |
| SCHEMBL8773510 | 0.79 | CNR2 (0.64) | HDAC6LTB4R2CNR2LMNAPKM | |
| SCHEMBL9833716 | 0.78 | ALOX5 (0.72) | ALOX5KDM4AKDM4CKDM5APHF8 | |
| SCHEMBL9836494 | 0.78 | ALOX5 (0.72) | ALOX5KDM4AKDM4CKDM5APHF8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7517995-B2 | Thiazolyl-dihydro-cyclopentapyrazole | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2009-04-14 | — | — | US | disclosed |
| US-20070238746-A1 | THIAZOLYL-DIHYDRO-CHINAZOLINE | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2007-10-11 | — | — | US | disclosed |
| US-20070238730-A1 | THIAZOLYL-DIHYDRO-CYCLOPENTAPYRAZOLE | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2007-10-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070238746-A1 | THIAZOLYL-DIHYDRO-CHINAZOLINE | CYP3A7, UGT2B7, UGT1A7 | ALOX5 4361/4885KDM4A 4324/4885KDM4C 3871/4885 |
| US-20070238730-A1 | THIAZOLYL-DIHYDRO-CYCLOPENTAPYRAZOLE | REN, ROR1, RORB | ALOX5 2810/4885KDM4A 4653/4885KDM4C 4585/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.